On the wall of Gates Found.: If you want to go fast, go alone. If you want to go far, go together. Today in @ScienceMagazine the first results of the global #CoVIC collaboration: from >50 Ab discovery engines across 4 continents, which antibodies retain activity alpha to epsilon. 
science.org/doi/10.1126/sc…
Thank you @carterra_bio for the massive footprint analysis, @BjoernPeters2 for the publicly available database covic.lji.org, Tomaras lab for binding analysis, @slschendel for conducting the orchestra & my lab members @ljiresearch for all the EM.
Thank you @carterra_bio for the massive footprint analysis, @BjoernPeters2 for the publicly available database covic.lji.org, Tomaras lab for binding analysis, @slschendel for conducting the orchestra & my lab members @ljiresearch for all the EM.
Electron microscopy, of #CoVIC therapeutic IgG in complex with #SARSCoV2 spike, depicts how antibodies against key epitopes bind singly, bivalently, or bridge spikes together. Structure work led and coordinated by @LassaHunter Haoyang Li. science.org/doi/10.1126/sc…
Neutralization links footprints to function and durability despite emergence of #variants alpha to epsilon. Instructor Kathryn Hastie @ljiresearch pulled off a heroic effort with great precision to evaluate the #CoVIC panel against Pandora's box of emerging #SARSCoV2 variants.
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