I imagine some scientists are now praying that one of the most well-funded, prolific, cutting-edge labs in the world suddenly didn’t have the will, funding or ingenuity to follow through and expand on the SARSr-CoV engineering ideas they proposed in early 2018. #OriginsOfCovid
This is an astute observation by @zeynep

The more senior authors and signatories of @TheLancet letters and the Holmes et al. @CellCellPress paper should be approached for extended comment on the EcoHealth proposal.
To do that, we really need the best of the best journalists to cover this story. @theintercept @fastlerner @MaraHvistendahl @maiahibbett and @TheAtlantic @danengber have made valiant efforts to authenticate the document and to juxtapose arguments from experts on both sides.
This is not an easy space for journalists to occupy, not just because the science itself is super complex, but also because you’ll have to grapple with the possibly more complex science ecosystem.
It’s the most challenging for experts and journalists who are primarily affiliated with fields, institutions or organizations that have, intentionally or otherwise, made it near impossible to raise doubts about the #OriginsOfCovid without facing inordinate backlash.
But it is also the experts and journalists in these positions who have the ability to solicit a response from and hold accountable key characters in this issue, and advance an accurate and fair public understanding of how this pandemic might have started.
I would describe @TheAtlantic as one of the most scientist-friendly news organizations that wouldn’t misrepresent quotes from scientists for the sake of clicks or scandal. There’s little to no reason to decline comment.
The same applies to @theintercept yet no response from @EcoHealthNYC “despite having answered previous queries from The Intercept about the group’s government-funded coronavirus research” or Dr Ralph Baric, a subcontractor on the grant proposal.
theintercept.com/2021/09/23/cor…
@theintercept @EcoHealthNYC Going to let the junior PIs and postdocs handle this PR disaster then...

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More from @Ayjchan

25 Sep
“The pattern here is unmistakable: At every turn, what could be important information has been withheld.”

“scientists agree that the very fact that these experiments were even on the radar raises significant concerns”

Good to see minds changing. theatlantic.com/science/archiv…
I don’t think the window for possible work on a SARS2 precursor was that narrow (early 2018 to fall 2019) @acritschristoph

We don’t know when the preliminary work on FCS detection in deep sequencing data had been conducted and when a precursor might have been found.
Thanks to painstaking work by @franciscodeasis we know that we have near zero insight to the viruses sampled by the WIV after 2015. And their entire database is missing. We also have no access to their deep sequencing data which wouldn’t regularly be uploaded to databases.
Read 8 tweets
23 Sep
This is the article to read. On point explanation of the backstory and importance of the newly leaked EcoHealth documents by Drastic. Full range of expert perspectives. Beautiful reporting by ⁦@fastlerner⁩ ⁦@maiahibbett⁩ ⁦@theintercepttheintercept.com/2021/09/23/cor…
Opinions ranged from “There are zero data to support a lab origin ‘notion’… the benefits [of the EcoHealth proposal] far, far outweigh the risk.”

To “This is doing everything that people say is going to cause a pandemic if you do it.”
“I find it really disappointing that one of the members of the joint WHO-China team… investigating this, are actually on this proposal, knew that this line of research was at least under consideration, and didn’t mention it all.” - @jbloom_lab
Read 5 tweets
21 Sep
When a new SARSr-CoV with a new cleavage site insertion was causing an outbreak in Wuhan, how many of the scientists involved in the March 2018 DEFUSE proposal remembered their Wuhan colleagues had a roadmap for experimenting with new SARSr-CoVs with new cleavage site insertions?
This proposal to DARPA for $14.2 million, submitted in early 2018, was like the EcoHealth-WIV NIH proposal but on steroids.

It is looking increasingly authentic. Basically only lacking confirmation from DARPA or any one of the scientists in the document.
drasticresearch.files.wordpress.com/2021/09/main-d…
Some scientists might argue that the proposal was not successful - DARPA did not fund it. But it doesn't mean it wasn't already ongoing even at the time of proposal.

When you see this level of detail, there's a good chance some preliminary work has been done.
Read 13 tweets
20 Sep
Possible ways for a virus with an ancestral origin in bats to have made its way to Wuhan.

It's good that scientists are finding more bat viruses related to SARS2 in South China/SE Asia, but it still doesn't identify the route by which SARS2 arrived in Wuhan.
Yes, it took about a decade to track the closest bat virus relatives to SARS1.

But only 2 months from isolating the virus to find the proximal animal source in Guangzhou in 2003, and only days in 2004.

Read more here:

Despite less advanced technologies, Chinese investigators rapidly tracked down early cases, likely animal sources, and a well-substantiated path for SARS1 to have been introduced into human beings via the trade of infected animals.
ayjchan.medium.com/a-response-to-…
Read 6 tweets
20 Sep
Wish the @cnn @drsanjaygupta special was longer. Must have so much more valuable footage from each of the interviewees. Q&A with @PeterDaszak and Dr Ralph Baric was 👌 Thank you for having me on the show ☄️producer and team!
Take home messages were:

1. No definitive evidence for natural or lab origin - jury still out

2. No actual investigation of lab origin yet

3. Extensive SARS-related virus work done at low biosafety levels

4. Large pathogen database MIA

5. But natural origins still possible
Ancestral bat origin most likely according to most experts and WHO.

Problem is we don’t know how a bat virus evolved and transformed into the SARS2 virus that was detected in Wuhan in December 2019.

Were research activities involved?
Read 5 tweets
19 Sep
It’s difficult to reconcile this interview of the former DNI with the recent declassified summary by the IC. If there is compelling evidence of a lab origin (which I had heard of back in August) then why did the IC agencies largely not reach even low confidence conclusions?
Reminder of how the IC implements ruled regarding just natural exposure vs lab origin:
Read 4 tweets

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