Tweet

Jonathan Mesiano-Crookston🌬️🔅 @/#COVIDisAirborne

27 Sep, 5 tweets, 2 min read

There is something gloriously vindicative that our best weapon against SARS-CoV-2 might be molnupiravir, which causes the virus replication to suck in the wrong molecule and replicate improperly, ruining its mRNA.

WHAT YOU DO TO US WE WILL DO BACK TO YOU, VIRUS THING

And, for those wanting to do the learnings:

Kabinger, Florian, et al ‘Mechanism of Molnupiravir-Induced SARS-CoV-2 Mutagenesis’. Nature Structural & Molecular Biology 28, no. 9 (September 2021): 740–46. doi.org/10.1038/s41594….

Malone, Brandon, and Elizabeth A. Campbell. ‘Molnupiravir: Coding for Catastrophe’. Nature Structural & Molecular Biology 28, no. 9 (September 2021): 706–8. doi.org/10.1038/s41594….

ncbi.nlm.nih.gov/pmc/articles/P…

Very early days of the clinical trials, in case people are wondering.

clinicaltrialsarena.com/news/molnupira…

• • •

Missing some Tweet in this thread? You can try to force a refresh

This Thread may be Removed Anytime!

Twitter may remove this content at anytime! Save it as PDF for later use!

More from @jmcrookston

Jonathan Mesiano-Crookston🌬️🔅 @/#COVIDisAirborne

@jmcrookston

29 Sep

Grr.

Fundamental breach is NOT dead as a term meaning "big breach of contract".

It's only dead as meaning "automatically destroys restrictive covenants"

Yeah, I'm subtweeting the real world, and one person, and they'll never see it. TAKE THAT.

I totally won that.

Read 4 tweets

Jonathan Mesiano-Crookston🌬️🔅 @/#COVIDisAirborne

@jmcrookston

28 Sep

A(H1N1)pdm09 influenza viruses replicating in ferret upper or lower respiratory tract differed in onward transmission potential by air

Chenyi Xie, Wen Su, Sin Fun Sia, Ka-Tim Choy, Steven Morrell, Jie Zhou, Malik Peiris, Jesse Bloom, Hui-Ling Yen
academic.oup.com/jid/advance-ar…

Background
A(H1N1)pdm09 influenza viruses replicate efficiently in respiratory epithelia and are transmitted via respiratory droplets and aerosols expelled by infected hosts. The relative onward transmission potential of influenza viruses replicating in the upper and lower

Read 7 tweets

Jonathan Mesiano-Crookston🌬️🔅 @/#COVIDisAirborne

@jmcrookston

27 Sep

A few articles about randomized controlled trials (RCTs).

apa.org/monitor/2010/0…

ncbi.nlm.nih.gov/pmc/articles/P…

Read 5 tweets

Jonathan Mesiano-Crookston🌬️🔅 @/#COVIDisAirborne

@jmcrookston

26 Sep

https://twitter.com/jmcrookston/status/1442204003199164424

This is why we can't have nice things. "Experts" retweeting garbage.

https://twitter.com/jmcrookston/status/1442204003199164424

Oh boy, paper number 2 already raising a red flag ...

Number 3 was an interview with some guy from Iceland who said kids less likely to transmit to parents.

1. Not a study, just an interview.

2. Oh, but what date was the interview you ask?

April _2020_

Read 4 tweets

Jonathan Mesiano-Crookston🌬️🔅 @/#COVIDisAirborne

@jmcrookston

25 Sep

Listen, we need to be calm and rational and follow the evidence.

We need to weigh the danger to a possibly fatal virus, which kills you by slowly strangling your ability to breathe and turning your lungs to gelatine, with the fact that many HCW find masks hot.

None of YOUR studies are any good because they are not randomized controlled trials, with suitable sample sizes, so we do not know masks work.

On the flip side, we know masks don't work because they were implemented in ImagineLand and cases still went up, as it said in the newspaper, thus proving my point.

Read 19 tweets