1/7 Here's your response, @RawsthorneMat!

From where I'm standing, this insight isn't new. @bringmann_laura, @aaronjfisher Ellen Hamaker, @fionnekebos, @Oisin_Ryan_, @jonashaslbeck, Marieke Wichers, et al have been grappling with this for 1/2 decade.

2/7 In our own work, we've written about this in detail, too. CF our 2017 challenges paper with @angecramer in which we have a dedicated section on the topic; our 2017 review paper that lists this challenge; and my 2021 Psych Inquiry paper features inference gap as core topic.
3/7 I also briefly went back to the very first workshop I taught 2016, which (like all future ones) had a dedicated section on this problem. So from where I'm standing, the field isn't "finally recognizing" this issue; it's well known, & folks have struggled & grappled with it.
4/7 I can only speak for myself, but I believe the lit has been grappling with this issue because it's really important to avoid the inference gap between theory and model/data, and because it's really difficult to do so.
5/7 Working with temporal data, it quickly becomes obvious that this doesn't solve most issues of dynamic inferences. E.g. folks use temporally invariant models, but dynamic processes are like variable over time.

+ issues of measurement, modeling, time frames, power, etc.
6/7 Temporal data don't buy you causal inference: causal assumptions + data do. From this perspective, I've really enjoyed the historical causal inference literature. Many within-person processes, e.g. smoking -> lung cancer, were initially observed in cross-sectional data ofc.
7/7 Conclusion: I've become a bit of a pluralist over the last few years, inspired by e.g. P Feyerabend & S Mitchell.

Using appropriate statistical models/data to help you bring your data to bear on your theories is really important, but really hard.

eiko-fried.com/on-theory/

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More from @EikoFried

24 Sep
Just finished my keynote at @conference_2021 on "Mental health: studying systems instead of syndromes". You can find slides & new preprint here: osf.io/bm6r5/. Really enjoyed making a completely new presentation from scratch.

🧵
The first barrier to progress I talk about is diagnostic literalism and its consequences: while many of us don't believe in MDD or schizophrenia as "natural disease units" in the world, case-control research in our field is often carried out in that way.
I discuss some historical evidence on how arbitrary many of the categories and thresholds we have today in DSM-5 were, and that DSM-5 may look quite different today if minor things had gone differently.

This means diagnostic categories are not natural kinds.
Read 9 tweets
22 Jul
There is a broad coalition in 🇳🇱 academia trying to improve the status quo.

Not surprisingly, there were quick responses to a number of recent pieces pushing back against reforms. You can find these rebuttals here. 🧵
1. "Science is NOT like competitive sports."(🇬🇧)
By @YALeiden members & colleagues at @UniLeiden.

voicesyoungacademics.nl/articles/scien…
2. "We need to get rid of numeracy in science."(🇳🇱)
By a coalition of early career scholars. You can sign the document at the bottom.

scienceguide.nl/2021/07/we-moe…
Read 4 tweets
20 Jul
Dutch universities are making a move to abandon the impact factor in recognition and reward considerations. A group of 170 Dutch academics posted a critical response to this initiative. I summarize why these responses fail to convince me. 🧵
First, for context, here the initiative by @UniUtrecht we are talking about: changing rewards and recognitions. Other universities have similar initiatives.

nature.com/articles/d4158…
Here the rebuttal by 171 academics in the Netherlands, most of whom appear to be full professors. It's in NL, but google translate works well for Dutch websites.

scienceguide.nl/2021/07/nieuwe…
Read 17 tweets
19 Apr
1/ National Institute for Health & Care Excellence does not recommend #esketamine to treat #depression bc effectiveness unclear (low quality trials), problematic economic model (short-term treatment, depression lasts long). Cost/benefit not sufficient to recommend treatment.
2/ Here the recommendation (nice.org.uk/consultations/…).

Thanks for @PloederlM for sharing.
3/ Agreed that published literature is low quality. Samples are generally too small to draw inferences from the samples to the population; there are recent studies without placebo groups (how does that even get funded in 2020); when placebo groups exist, they are often not >>
Read 5 tweets
10 Apr
"Hans-Ulrich Wittchen .. is under fire after an investigation into one of his studies found evidence of manipulation—and elaborate efforts to cover up the misdeed. The investigation report .. also shows Wittchen intimidated whistleblowers"

science.sciencemag.org/content/372/65…
(I haven't vetted this, and cannot access the full paywalled article on my phone; just sharing because it may be of interest to others)
April 2019 article about this topic (in German)

sueddeutsche.de/gesundheit/med…
Read 4 tweets
9 Apr
Brief comment on the new "breakthrough study" on #depression blood tests. 🧵

TLDR: there is no blood test for depression.

neurosciencenews.com/depression-bip…
1/ A test helps to determine whether you have a feature or not.

Good tests are precise: they predict a feature well, have high sensitivity/specificity, & low false positives/negatives.
2/ Precise biological tests do not exist for the most common mental disorders. There are some weak biological correlates for depression, but a weak correlate is not a test, the same way that a weak correlate of COVID (coughing) is not a test for COVID.
Read 16 tweets

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