Over 7 billion Covid-19 vaccine doses have been produced globally to date, with >1.35 billion more doses produced each month now.

Sinovac and Sinopharm produce the greatest number of vaccines monthly, with Pfizer and AstraZeneca not far behind. 1/
By the end of this year the world is likely to produce over 12 billion vaccine doses of all vaccine types.

By June 2022 the number produced could reach double that – 24 billion doses (assuming all goes well, and it usually doesn’t) 2/
Even after reserving doses for boosters, Western countries are likely to accumulate large stockpiles of vaccines over the coming months, perhaps as many as 1.2 billion doses by the end of this year.

These “surplus” doses could be redistributed to lower income countries. 3/
Adding up expected supply purchased through COVAX, bilateral deals and donations, and potential re-distributions, lower income countries could have access to sufficient doses for 70% of their populations by May 2022 4/
Having systems ready to distribute these doses is another matter, as access is not the same as getting those doses into arms.

For one thing, almost 70% of potentially re-distributable vaccine doses are mRNA vaccines with stricter cold-chain requirements 5/
If production and redistribution continues to ramp up, it is possible that by early next year the most pressing constraints on vaccinating populations in lower income countries will be related to distribution, rather than supply.
The above estimates on global Covid-19 vaccine production come from @airfinity, presenting at a @CGDev event earlier today.

Thanks @glassmanamanda and CGD for hosting the event. 6/
cgdev.org/event/covid-19…

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More from @joshmich

25 Aug
Keeping a wary eye on Covid trends in South America. The good: cases/deaths there have come down from devastating peaks a few months back, and there’s progress on vaccinations. The bad: Delta may have only begun to circulate, and questions about vaccine efficacy
Most countries in the region have fully vaccinated between 20 and 40% of their populations; Chile and Uruguay stand out, with >70% fully vaccinated. Countries use a mix of vaccines, mostly Chinese inactivated vaccines (Sinovac and Sinopharm), plus some Pfizer & AstraZeneca
Chinese vaccines have lower effectiveness vs symptomatic disease but protect vs hospitalizations and death.
Chile estimated the Sinovac VE vs. symptomatic Covid at 58%, and 86% vs hospitalization. For Pfizer: 88% and 97%, AZ: 68% and 100%, respectively
minsal.cl/wp-content/upl…
Read 11 tweets
23 Aug
Some initial thoughts on full FDA approval of the Pfizer vaccine and what it might mean for vaccine acceptance in the US, based on @KFF polling and policy work
A commonly referenced finding from KFF's vaccine monitor is that 3 in 10 unvaccinated people reported they'd be more likely to get the vaccine upon full FDA approval
kff.org/coronavirus-co…
Still, I don't think it means that if unvaccinated people hear the news about full FDA approval 3 in 10 of will all of a sudden decide to get the shot based on that alone.
Read 8 tweets
21 May
G20 summit today featured many pledges, promises and proposals to address global gaps in COVID19 vaccine access. We'll have to see how many of these become concrete actions in the weeks and months ahead.
reuters.com/world/g20-heal…
Pfizer promised to provide 2 billion doses "at cost" for lower income countries over the next 18 months: 1 billion by the end of this year and another billion by the middle of 2022.
reuters.com/business/healt…
.@gavi and J&J announced a purchase agreement of 200 million doses of the J&J vaccine for distribution through COVAX this year
gavi.org/news/media-roo…
Read 6 tweets
15 Apr
Important data on "breakthrough" infections: CDC says 5,800 infections documented so far in the US, of which 396 (7%) needed to be hospitalized. About 77 million people have been fully vaccinated in the US.
cnn.com/2021/04/14/hea…
CDC says a "little over 40% of the infections were in people 60 or more years of age" but hard to draw too many conclusions from that given that the preponderance of the vaccinated are in that age group, too.
We knew these infections would occur, and that some could lead to severe disease and even death. In this article alone, three different experts used the phrase "not surprising" to describe the phenomenon. Vaccines are not 100% protective.
washingtonpost.com/health/2021/04…
Read 8 tweets
13 Apr
In light of J&J news, of primary concern with regard to vaccine confidence in the US is the 15-20% of adults still on the fence about getting vaccinated. Could the pause, and the messaging around it, change minds from "wait and see" to "no thanks"?
kff.org/coronavirus-co… Image
The most common concerns about vaccines in the "wait and see" group revolve around safety and side effects, so if a perception takes hold - for whatever reason - that a vaccine is "unsafe" it could have implications for willingness to be vaccinated especially in this group. Image
Can't predict how things will play out here, but concerning precedent that several European countries saw a decline in confidence in the AstraZeneca vaccine after a week-long pause initiated for similar reasons as we're seeing for J&J
dw.com/en/european-tr…
Read 6 tweets
19 Jan
30% of Israel's population has received at least 1 dose of Covid-19 vaccine, but no indications yet that case numbers are coming down there (chart).

A few reasons why this might be:

1) Cases reported now were infected 7+ days ago, when vaccinations were lower Image
2) Less than 500,000 (out of ~2.7 M vaccinated) have so far received a 2nd dose. A single dose is "less effective than we hoped" in providing protection, according to Israeli health leaders.
theguardian.com/world/2021/jan…
3) Israel has vaccinated by age, starting with older persons, vaccinating to date:
80% of 70+
68% of 60-69
50% of 50-59
28% 40-49

Older ages are protected from severe disease, but younger ages typically contribute most to transmission
timesofisrael.com/israelis-aged-…
Read 6 tweets

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