Based on neutralizing antibody titers at day 15 after boost:
After Moderna:
Moderna > Pfizer > J&J
After J&J:
Moderna > Pfizer >>> J&J
After Pfizer:
Moderna > Pfizer > J&J
4/ Note that this study looks only at binding and neutralizing antibody titers out to 15 days after boost.
Data on 29 days after boost are pending for some of these groups, so can't compare out that far yet.
5/ We don't know how much antibody levels will wane (AND THEY WILL) over time for each group.
We also don't know what the impact of these booster doses is on B- and T-cell immunity,
or risk of infection, symptomatic disease, hospitalization, or death.
6/ We also don't know if boosters performed differently by demographic group (e.g. elderly, immunocompromised).
And this only looked at binding and neutralizing antibody titers vs D614G (early variant) not vs the Delta, Beta, or other variants.
7/ Note that the study participants were overwhelmingly white.
All were considered healthy.
(So I assume that means none had underlying co-morbidities–like heart disease, diabetes, or obesity–that would predispose to severe disease if one were infected?)
8/ One more point on neutralizing antibody titers:
These are a reflection of:
Quantity of antibodies
Affinity of antibodies
Breadth of antibodies
It would be interesting to see affinity vs breadth of antibodies by regimen.
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- To become more transmissible (e.g. the Alpha & Delta variants)
- To evade immune responses (e.g. the Beta & Gamma variants)
- To become more virulent
May: NYS adopted CDC guidance for fully-vaxxed
June: end of NYS’ state of emergency (⬇️mask-wearing, distancing etc)
July: CDC recommended mask usage for fully-vaxxed based on transmission levels
July: Delta became dominant
2/ COVID vaccine effectiveness vs HOSPITALIZATION:
Among 18-49 year-olds:
Pfizer/Moderna: >90%
* except June with 87% for Moderna
J&J: >90%
* except June with 54%
* related to behavior? (see #1)
3/ COVID vaccine effectiveness vs HOSPITALIZATION:
Among 50-64 year-olds:
Pfizer/Moderna: >90%
J&J: 87-93%
2/ WE NEED THE SERENITY TO ACCEPT THE THINGS WE CANNOT CHANGE:
COVID is here to stay.
SARS-CoV-2 cannot be eliminated.
The virus will become endemic (i.e. ongoing community transmission).
3/ ...THE COURAGE TO CHANGE THE THINGS WE CAN:
Maximize use of testing, ventilation, & air filtration.
Tailor based on individual risk.
Masks in some settings.
Support caregivers.
Paid sick leave.
Better treatment/care for long COVID patients as well as disability benefits.