Why SARS-CoV was more virulent than SARS-CoV-2
(part of the reason, temps, replication kinetics) and why temperature won't tell us a lot about origins or intermediary animals.
(part of the reason, temps, replication kinetics) and why temperature won't tell us a lot about origins or intermediary animals.
Bats have higher temps than minks and civets.
But just because it transmits in the air doesn't mean that it needs to be a (cool temp) respiratory infection. Could be an enteric one in the animals, where it's hotter.
But just because it transmits in the air doesn't mean that it needs to be a (cool temp) respiratory infection. Could be an enteric one in the animals, where it's hotter.
Colds are cool, flu is not, avian flu is hot.
Our best shot of SARS-CoV-2 attenuating is it becoming less infectious (receptor binding) or competent (replication) @ higher temps.
The others (loss of E) becoming less fusogenic, decrease in fitness + replication comp, losing the furin cleavage site, etc. much less likely.
The others (loss of E) becoming less fusogenic, decrease in fitness + replication comp, losing the furin cleavage site, etc. much less likely.
Ofc, we could target the features we want gone in a vaccine.
Or we could run simulations to predict viral evolution, although I'm not a big believer (in sims).
But I'm not a big believer in flying blind or inaction or "nature will sort this one out since we've been nice to her"
Or we could run simulations to predict viral evolution, although I'm not a big believer (in sims).
But I'm not a big believer in flying blind or inaction or "nature will sort this one out since we've been nice to her"
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