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15 Oct, 5 tweets, 1 min read
Parvalbumin may be another reason for the added benefits from eating whole seafood rather than fish oil

It is produced endogenously, and plays a role in photoreceptor activity, neurogenesis, muscle contraction, memory formation, stress response, and neuroprotection
It does seem to be at least somewhat orally absorbed since it is one of the mediators of fish allergy (but not shellfish)

As long as you're not allergic to seafood however it may still be absorbed but instead may be redistributed into various tissues
Most parvalbumin is likely broken down into amino acids during digestion, similar to what occurs when you take a collagen supplement, but the benefit may be more in providing higher amounts of the same amino acids used specifically for parvalbumin synthesis
Of course you can also focus on ways to increase parvalbumin production in the body, including:

- balancing circadian rhythm
- exercise
- heat/cold exposure (via PGC1a)
- coleus forskholii (via increased cAMP)
- anything that increases BDNF (including seafood!)
This one is a rodent study, but also showed a reduction in parvalbumin-containing GABAergic neurons in young rodents fed high amounts of sucrose daily
pdfs.semanticscholar.org/efaa/649d50eae…

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More from @ck_eternity_

11 Oct
When megadoses of vitamin D supplements are taken orally, the body may actually shunt conversion away from the active form of vitamin D (1,25D), instead increasing production of its analogs in the epi-25D pathway
These analogs are significantly less calcemic, so this shunt may be used to minimize increases in serum calcium seen with excess vitamin D

Unfortunately this pathway has not been studied in humans, but we see this consistently in studies in rodents with supplemental vitamin D
Infants also demonstrate a higher ratio of epi-25D to 1,25D and 25D (aka D3), perhaps to preserve calcium in the skeletal system as much as possible during early development
Read 8 tweets
11 Oct
Bowel flush from high doses of magnesium is caused by excess of it reaching the large intestine/colon

Magnesium is hydroscopic, so it draws water more than other minerals, and past the small intestine there is almost no ability to absorb it so it pulls water into the bowel
The flush reaction is directly proportionate to the unabsorbed magnesium fraction

This also plays a role in why forms that are less soluble in water like magnesium hydroxide, citrate, or oxide, are the most laxative as they are the least well-absorbed
The solution to minimize flush is to opt for more soluble forms like magnesium chloride, and to space out intake as much as possible throughout the day

I like to fill a liter jar with water and add 1-2tsp mag chloride to gradually drink, start small (~0.5 tsp) and taper up
Read 4 tweets
11 Oct
The idea that free radicals = bad and antioxidants = good is a major oversimplification

When we talk about redox state it's not just about maintaining as little oxidation as possible, but rather keeping an appropriate balance in place between reduction and oxidation

(thread)
Chemistry 101:

Put simply, oxidation refers to any chemical reaction involving the loss of an electron, when something is oxidized it just means that one of its electrons is transferred to another molecule
Reduction is the inverse of this, a molecule or atom gaining an electron from another molecule or atom

As you can see, it's impossible for reduction to occur without oxidation, and vice versa, hence the shorthand "redox" refers to this category of reactions
Read 16 tweets
9 Oct
The idea of a "debate" around CICO is pretty ridiculous, in the sense that the role that thermodynamics plays in metabolism is well-established and agreed on by everyone

What we're actually seeing is a shift in emphasis away from calories in and more towards calories out
What I mean by this is that more and more nutritionists seems to be recognizing the error in the initial premise of the amount of calories eaten being the only significant factor in weight gain/loss

This is obvious in cases like hypothyroidism, etc, where metabolism is impaired
This isn't a new idea or mutually exclusive with CICO, just a shift in emphasis from one side of the equation to the other

I think most everyone would agree that the amount of food you eat matters, but also that lack of exercise, hormone imbalance, etc, can impair weight loss
Read 8 tweets
8 Oct
I've been digging more into the connections between the "big three" sex hormones (testosterone, estrogen, and progesterone), and glutamatergic disorders like epilepsy
Interestingly, androgens like testosterone and DHT are actually anticonvulsant, which seems counterintuitive since they increase force production

This seems to result from their conversion into the neurosteroids androsterone and 3a-androstenediol which increase GABA sensitivity
Progesterone is also anticonvulsant as a result increased neurosteroid production, most notably allopregnanolone, but to lesser extent other dihydroprogesterone derivatives
Read 6 tweets
7 Oct
If I had a few million $ to allocate towards developing an herb into a medical therapy, conducting clinical trials on it, etc, I would choose bacopa

Specifically, the possible role of bacopa extracts in improving epilepsy long term
pubmed.ncbi.nlm.nih.gov/20821261/
pubmed.ncbi.nlm.nih.gov/19944749/
I've reviewed hundreds of rodent and human studies on various herbs and the potential benefits of bacopa in epilepsy have always stood out to me as being some of the most promising, yet the relevant human data seems to be totally lacking
When we consider the role that GABA/glutamate imbalances play in nearly every mental illness and neurodegenerative disorder, the potential applications of these herbs is extensive
Read 4 tweets

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