Thread by @caitlyntduffy

Over 300,000 children are diagnosed with cancer every year. Cancer is the leading cause of death in children around the world, but what's the most important factor that determines childhood cancer survival?
#ChildhoodCancer # #ph260720 via @WHO

Despite the influence of cancer genetics, disease stage, or age of the child, the most important factor that determines childhood cancer survival is where they are born.
#ChildhoodCancer #ph260720
via sciencedirect.com/science/articl…

Over 80% of children with cancer live in low- and middle-income countries where 4 out of 5 children die from their disease, versus high income countries where 4 out of 5 children survive. This difference is known as the pediatric cancer survival gap.#ph260720 #ChildhoodCancer

This survival gap is pediatric cancer represents one of the greatest public health disparities.
#ChildhoodCancer #ph260720
via pubmed.ncbi.nlm.nih.gov/28806362/

Poor survival for children with cancer in low-and middle-income countries is due to many different factors, however one of the biggest problems is limited access to essential and novel medications.
#ChildhoodCancer #ph260720
via pubmed.ncbi.nlm.nih.gov/23295716/

5 years after FDA approval, less than 22% of new medications are available in low-and middle-income countries.
#ChildhoodCancer #ph260720
via pubmed.ncbi.nlm.nih.gov/30582430/

Physicians from middle-income countries cite the #1 barrier to improving cancer care in their centers is limited access to new medications.
#ChildhoodCancer #ph260720
via pubmed.ncbi.nlm.nih.gov/29244632/

Rates of pediatric cancer are increasing in low-and middle-income countries. It is crucial to improve access to these therapies, but no framework exists to systematically translate these lifesaving medicines. So how do we help overcome this disparity?
#ChildhoodCancer #ph260720

Implementation science uses frameworks to overcome barriers, bring “what works” (like evidence-based medicines) to the people would benefit from them the most, and does so in a way that prioritizes safety, adapts to, and maximizes local resources. #ph260720 #impsci

By embracing implementation science in pediatric cancer on a global scale, we can increase access to evidence-based medicines & improve cure, so that where you are born doesn't determine if a child lives or dies from their cancer #ph260720 #ChildhoodCancer via @TheLancetOncol