So...still fighting over the false choice of Phase 3 vs challenge trials? Even in a pandemic & in countries hardly trying to limit spread, the narrow pathway to vaccines for emergency use was a tightrope & key safety signals were missed. @hic_vac @1daysooner /1 
Development of new vaccines requires someone to be infected somewhere. /2 mja.com.au/journal/2020/n…
Phase 3 trials aren't generalisable just because they are big. /3 jme.bmj.com/content/early/…
Even big & expensive Phase 3 trials miss rare safety signals. /4 pubmed.ncbi.nlm.nih.gov/26414015/
Field trials & challenge trials are useful, in different ways. /5 thelancet.com/article/S1473-…
We need to think differently to develop the new vaccines we need for major global infectious diseases, besides COVID-19. Here's how one group of authors thought we might do it. /end ncbi.nlm.nih.gov/pmc/articles/P…
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