Great article by @EricSylvers @WSJ on what life would look like in a country with high vaccination rate that proceeds cautiously with reopening.

The virus still circulates but deaths are very low. Life gets closer to normal with sensible precautions. wsj.com/articles/endem…
Amazing vaccination stats: 89% of the population have received at least one dose.

Almost 100% of those age 50+. 95% age 25-49.
We need to get over the mind set that wearing masks in some settings or needing to show proof of vaccination is an infringement on freedom. And realize that freedom comes by adopting sensible measures.

It's the repeated waves that pose a bigger threat to our freedom.
Compare pre vaccine and post vaccine waves in Portugal. You see the mitigating effect vaccines have on deaths: very low deaths in post vaccine wave. Similar to what we have seen in many other well vaccinated countries.

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More from @VincentRK

25 Oct
On Jan 24, 2020 @DrEricDing posted a massive warning about the impending pandemic: The Holy Mother of God thread.

"We are now faced with the most virulent virus 🦠 epidemic the world has ever seen," Eric wrote.

As I read his thread again today, all of it has sadly come true
1/
He wrote:

"possibly an unchecked pandemic that the world has not seen since the 1918 Spanish Influenza. Let’s hope it doesn’t reach that level but we now live in the modern world 🌎 with faster ✈️+ 🚞 than 1918. @WHO and @CDCgov needs to declare public health emergency ASAP!"
2/
People quarreled with the R0 that was in @DrEricDing's thread, but most epidemiologists and leaders and organizations missed the forest for the trees.

We know what happened since:

240 million cases worldwide
5 million deaths

46 million cases in the US
>750,000 deaths

3/
Read 6 tweets
24 Oct
Alabama has lost more lives due to COVID in 2021 than other US states. More than 200 deaths per 100K population.

Vaccination rate in Alabama is 47th of 50 states. Only 44% of the population are fully vaccinated.
>400,000 cases this year. >10,000 deaths.
Some other states that have lost an high rate of lives this year:
Read 6 tweets
23 Oct
For brand-name prescription drugs, U.S. prices can be > 2 to 4 times higher than prices in Australia, Canada, and France.

This is neither fair nor sustainable. Medicare must be able to negotiate prescription drug prices.
The VA negotiates. Medicare doesn't. Result: Medicare pays a lot more for the same drugs. gao.gov/prescription-d…
Mandating that Medicare provide prescription drug coverage benefit for the public while simultaneously mandating that Medicare cannot negotiate the price it pays but pay up whatever Pharma wants is one of the most inexplicable laws ever passed.
Read 4 tweets
21 Oct
"Absolute risk reduction" is being tossed around to question vaccine efficacy.

This is one of those things which highlights how a little knowledge is a dangerous thing.
There is a role for absolute risk reduction. Vaccine efficacy is not one of that.

Take measles vaccine. Let's say we give 10000 placebo and 10,000 vaccine

100 get measles with placebo and 0 get it with vaccine. Relative efficacy is 100%

Absolute risk reduction is 1%-0% =1%.
So are we going to go around saying measles vaccine has only 1% efficacy?
Read 5 tweets
21 Oct
A booster dose of vaccine reduces risk of COVID infection by 95%. Given the number of unvaccinated people, & the number or vulnerable vaccinated people, reducing infections to this degree is a big deal.

1/
Reducing infections reduces risk of deaths from Covid, morbidity from acute Covid, risk of long covid, risk of transmission to others, and the rise of mutants.

2/
The big question we grapple with now is not whether boosters work. (They do). It is the more difficult question of how boosters here will affect vaccine supply around the world.

3/
Read 6 tweets
21 Oct
Breaking: In the first randomized trial of a booster dose of vaccine, Pfizer vaccine shows 96% efficacy against COVID infection.

5 cases of COVID-19 in the booster group versus 109 cases in the non-booster group.
businesswire.com/news/home/2021…
Study done when delta was prevalent strain.

Large study with >10,000 participants age 16+.

Efficacy retained in key subgroups irrespective of age, sex, race, ethnicity, or comorbid conditions.
Note when a booster dose has 96% efficacy compared to those who had 2 doses of Pfizer, then you can figure out that vaccine efficacy between no vaccine versus 3 doses is >99%.
Read 5 tweets

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