1-dose J&J is ok for a while, but needs a 2nd dose of vaccine (any) by 6 months. Anytime after 2 months is fine. A short thread on the recent J&J data to the FDA . 🧵
fda.gov/advisory-commi…
fda.gov/advisory-commi…
J&J 1-dose clinical trial efficacy.
These data, from a placebo controlled clinical trial for efficacy + safety, are robust. They are also consistent w/ multiple "real world" studies. Efficacy v. cases, hospitalizations, and deaths isn't as good as mRNA vaccines, across 6 months.
These data, from a placebo controlled clinical trial for efficacy + safety, are robust. They are also consistent w/ multiple "real world" studies. Efficacy v. cases, hospitalizations, and deaths isn't as good as mRNA vaccines, across 6 months.
Or graphically:
Hence, a 2nd dose is needed.
The J&J 2-dose clinical trial (being termed a booster).
Definitely gives a boost in antibody responses. (Waiting for T cell data) medrxiv.org/content/10.110…
Definitely gives a boost in antibody responses. (Waiting for T cell data) medrxiv.org/content/10.110…
And gives a boost in vaccine efficacy.
(COV3001= 1-dose. COV3009= 2-dose)
Overall efficacy 75%.
If you just look at USA, 94%, with overlap
(COV3001= 1-dose. COV3009= 2-dose)
Overall efficacy 75%.
If you just look at USA, 94%, with overlap
Clinical trial shortcomings:
* Quite short term follow up after J&J 2-doses so far (36 day average).
* not many COVID-19 cases, so the efficacy calculations are not particularly tight.
* Quite short term follow up after J&J 2-doses so far (36 day average).
* not many COVID-19 cases, so the efficacy calculations are not particularly tight.
Overall, it is REALLY good to see these data! It clearly took a lot of work to get this far for the 2-dose J&J COVID-19 vaccine clinical trial!
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