1/ A Quantitative Risk Estimation Platform for Indoor Aerosol Transmission of #COVID19 (Open Access paper)

Some Cliff Notes in thread below.

onlinelibrary.wiley.com/doi/10.1111/ri…
2/ This paper offers a platform that is somewhat more mechanistic than traditional risk estimates for airborne infectious disease. It includes ability to include aerosol size distributions & emissions from infected individuals + particle fate mechanisms indoors.
3/ Insertion of control options (increasing ventilation, masks, filtration) in single zone systems can be employed. The model predicts particle deposition in the respiratory system of receptors & converts these to total volume of particle deposition.
4/ A dose-response model is included and can be easily changed as new data are available. The dose-response component is anchored to volume deposition based on a classic outbreak w/ ample metadata.
5/ This platform was tested to predict total infections for several other outbreaks and predicted in the ballpark for those cases using reasonable bounds on building/vehicle data when these data were not reported.
6/ It is a platform as defined in the paper and intended for continuous improvement in the future. Yes, there are uncertainties, just like any other model intended to predict transmission and infections in the built environment.
7/ But I am very pleased by initial results and the possibility to continue to improve the platform.

Thanks to great colleagues and co-authors - @Wymelenberg, @HoomanParhizkar, @ProfCharlesHaas. This was a fun project with substantial contributions by all.

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More from @CorsIAQ

21 Oct
1/ Indoor Air Quality in Schools
Some slides from a presentation on indoor air quality in schools a decade ago. It contains reference to what I thought were important/insightful papers at the time. A lot more slides than shown here. Will post at corsiaq.com
2/
3/
Read 18 tweets
12 Oct
1/ Don't be fooled by some air cleaning companies that claim their device is highly efficient. When claims are made about removing 95% or 99% of particles from air, this nearly always refers to % of particles removed THAT FLOW THROUGH THE DEVICE (single pass removal efficiency).
2/ A device can be 99.5% efficient & highly INEFFECTIVE if it has little flow moving through it. The product of fractional removal efficiency (max = 1.0) & volumetric flow rate (e.g. cubic feet per minute) is the important parameter (& known as CADR or Clean Air Delivery Rate).
3/ Example - Company for device 1 claims it removes 99.5% of particles from air (fractional single-pass removal efficiency = 0.995), but the device moves only 30 cfm of air (CADR = 0.995 x 30 cfm = 30 cfm).
Read 5 tweets
19 Sep
1/ Inhalation Dose
It's been about inhalation dose from day 1. We have not kept our eye on the ball. Critical pre-vaccination. Critical post-vaccination. Been writing & speaking about this for nearly 20 mos. Reducing inhalation dose is a must. Come on folks, just do it!
2/ Reducing Inhalation dose using layered interventions is still important, whether unvaccinated or vaccinated (breakthrough cases), in close contact (near field) or far field in the same indoor space, in a car or classroom, in a restaurant or apartment, young or old.
3/ Inhalation dose associated with virus laden aerosol particles is defined by the same variables (whether close contact or far field ---- don't bicker about one or the other - I've previously tweeted about this):

Dose(inhal,i) = C(i) x B x t x fdep(i)
Read 25 tweets
13 Sep
1/ I am really looking forward to meeting new students and helping new College of Engineering students to moove into their dorm rooms later this week.
2/ My message will be clear. Stay safe. Stay focused. Learn the fundamental principles and tools of your trade as you will be able to use these to change society for the better and to help heal the planet.
3/ While you are in college, take advantage of being on such a great campus. Join student groups & get to know faculty and staff. Ask for help when you need it. We are a community and are here for each other.
Read 5 tweets
5 Sep
1/ As a follow-up to my earlier email ....
First, the concentrations of ozone needed to disinfect indoor surfaces is significant and approach or exceed the IDLH (Immediately Dangerous to Life or Health) level. So, use of ozone should be done w/ great care, if done at all.
2/ Ozone (O3) is a moderate oxidant. It reacts with almost all indoor materials, some more than others, as well as oils that we add to or unknowingly leave behind (e.g., skin oils) on those surfaces.
3/ These reactions can (over time), lead to material degradation, e.g., brittleness of rubber seals, leaching of lead from lead-based paints, and even increased susceptibility of some materials to mold growth (research done in collaboration w/ @KerryKinney14 @ut_caee ).
Read 16 tweets
4 Sep
1/ I hope that we have collectively learned a lot (a very long list) from this pandemic. I fear that many have not.
2/ The overwhelming obvious: Vaccines reduce risk of hospitalization and death. Reducing inhalation dose of virus-laden aerosol particles reduces risk of infection, hospitalization and death.
3/ Masks, increased ventilation, appropriate filtration all reduce inhalation dose, and therefore are important weapons in reducing risk of infection, hospitalization and death.
Read 11 tweets

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