Thread by @DrDamluji

SURTAVI

No differences in death ,stroke, MI, or HF between TAVR and Surgery during longer follow-up

#TCT2021

Hemodynamics

Total AR and PVL

KCCQ no difference after 1 year

NYHA class at one year 1

Summary for SURTAVI

Self expanding valve

#TCT2021

Excellent!

5 year data for 4,000 patients is now out (intermediate risk).

@djc795

Economic outcomes of PARTNER #3

@djc795

Cost effectiveness study along side of PARTNER 3 trial

funded by Edwards

Costing: definitions

US population only

Medicare data link

Results Baseline

TAVR vs SAVR PARTNER 3 Economic Study

Index Hospital Costs

Follow-up Cost

Overall no cost difference

QALY difference (borderline?!)

#TCT2021

All costs and effects discounting

TAVR is cost effective

Subgroups (pre-specified)

Sensitivity analyses

#TCT2021

Sensitivity Analyses

Summary!

84% CI that we will improve outcomes and at the same time achieve cost effectiveness.

10 year outcomes will affect cost effectiveness - to come...

Outstanding presentation @djc795 @DrMauricioCohen

#TCT2021

"When mortality rate is the same between SAVR and TAVR: patient preference is what matter next."

"No one wants a sternotomy."

@djc795

#TCT2021

CHOICE CLOSURE

Vascular Closure for TAVR but this also applies to shock space also (Safety Bundle)

#TCT2021

@Radial_ICG @behnam_tehrani @agtruesdell @ShashankSinhaMD @JACCJournals

Available Evidence

Aim Choice Closure

Randomization: pure plug based vs primary suture based

#TCT2021

Inclusion and Exclusion

Primary Endpoint

Secondary Endpoints

Study Methods

Angioseal was used...

3 Locations in Germany

#TCT2021

Study Flow

258 MANTA vs 258 ProGlide

#TCT2021

Baseline Results

Vessel Characteristics

Procedural Details

Low ultrasound use?! @Radial_ICG

#TCT2021

Manta had higher complications!!

Important data!

#TCT2021

Subgroup analysis

Hospital Outcomes

30-Day Outcomes

#TCT2021

Limitation

Conclusion

Excellent trial @Mo_A_W

Applies to shock too

***Editorializing: Losing the wire access with MANTA is a big problem.

#SafetyBundle

#TCT2021

Comparison of a Pure Plug-Based versus a Primary Suture-Based Vascular Closure Device Strategy for Transfemoral Transcatheter Aortic Valve Replacement: The CHOICE-CLOSURE Randomized Clinical Trial

@CircAHA

ahajournals.org/doi/abs/10.116…