1/ #tweetorial

💠 Aggresive Nitroglycerin Usage in Acute Decompensated Heart Failure (ADHF)

➡️ Diuretics should not be considered first-line therapy in the ED treatment of patients with ADHF.

manualofmedicine.com/topics/cardiol…

#medtwitter #meded #foamed #cardioed #CardioTwitter
2/

➡️ The majority of ED patients who present with ADHF are not volume overloaded. Rather, their pulmonary congestion is due to volume redistribution.

➡️ High-dose nitroglycerin therapy should be initiated early in ADHF, especially in patients who are hypertensive.
3/

➡️ Often, these patients arrive to the ED by ambulance and receive sublingual nitroglycerin therapy (0.4 mg every 5 minutes) during their transport.

➡️ Do not begin a nitroglycerin infusion at a dose less than that provided by the sublingual route.
4/

➡️ Nitroglycerin doses of at least 120 mcg/min are needed to reduce capillary wedge pressure.

➡️ The nitroglycerin infusion can be rapidly increased to 400 mcg/min based upon clinical effect and patient symptoms.
5/

➡️ Noninvasive Ventilation (NIV) should be administered early and in conjunction with high-dose vasodilator therapy for AHDF.

➡️ Once the patient improves (decreased resp rate, decreased dyspnea, improved oxygenation, improved BP), diuretic therapy can be considered.
6/

➡️ Importantly, diuretics require adequate renal perfusion in order to be effective. During the initial ED evaluation and management when patients are in extremis, renal perfusion is poor, and diuretics are ineffective.

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More from @ManualOMedicine

Jan 11
1/ #tweetorial

💠 Caustic Ingestions - Key Points

➡️ Serious ingestions can immediately result in perforation, shock, and even death.

➡️ Caustic materials cause tissue injury by chemical reaction.

- Read More : manualofmedicine.com/topics/emergen…

#meded #foamed #medtwitter
2/

➡️ Acids cause coagulative necrosis, which results in a self-limiting burn pattern

➡️ Alkaline materials induce liquefactive necrosis with diffusion into deeper layers of the injured mucosa. Even low concentrations of alkaline ingestion can cause extensive injury.
3/

➡️ Caustic Ingestion can provoke injury from the mouth, the airway, down through the esophagus to the small intestine.

➡️ Long-term complications can lead to strictures and an increased risk of esophageal cancer.
Read 9 tweets

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