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Abdulla A. Damluji, MD, PhD Profile picture
@DrDamluji
Nov 15, 2021 • 12 tweets • 11 min read • Read on X
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Great session #AHA2021

Cardiovascular Quality and Outcomes: An International Collaboration

@UmeshKhotMD @emilycob
The push for cardiovascular interventions on the interventional level - beyond the U.S.

Mark Huffman of @NorthwesternU
Funding on the international level.

$50 million from @nih_nhlbi and $30 million from @AHAScience to improve the global cardiovascular care.

#AHA2021
Implementation research and health policy on the global stage #AHAQCOR
Quality of Care Measurement Globally.

@rohan_khera @Yale
Electronic Healthcare Systems in the World and Utilization of Data: A Focus on Quality Assurance of Data.

Excellent!!

@hmkyale @rohan_khera
On Sex Disparities on Cardiovascular Health: A Global Perspective

@hvanspall
Representation of Women in Clinical Trials Beyond
Care of Women is Suboptimal Relative to Men.

The age standardized deaths among women by social and economic status
The social and economic status and prevalence of HF by gender

Lower income regions, women, and CVD mortality

@UmeshKhotMD
Heart Failure Trials Globally

Africa and Asia are underrepresented!
The road to the future is highlighted below:

#QCOR21

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More from @DrDamluji

Abdulla A. Damluji, MD, PhD Profile picture
Mar 31
Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism: @NEJM

🥸 - good work #ACC25 @ACCinTouch

👇👇👇 Image
🥸1️⃣ In cancer-associated VTE, extended anticoagulation is common—but the dose remains uncertain. The API-CAT trial tested reduced-dose vs. full-dose apixaban after 6 months of initial therapy.
🥸2️⃣ 1,766 patients with active cancer and prior VTE were randomized to apixaban 2.5 mg BID or 5 mg BID for 12 months. Median follow-up was nearly 12 months.
Read 21 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Mar 31
Global Effect of Cardiovascular Risk Factors on Lifetime Estimates: @NEJM

🥸 Great work from Germany on global life time risk of CVD risk

😱 Summary

👇👇👇 Image
🥸1️⃣ Lifetime cardiovascular risk increases with the number of classic risk factors you carry at age 50. The Global Cardiovascular Risk Consortium analyzed over 2 million people to estimate how much risk factors shorten life and healthspan.
🥸2️⃣ Five risk factors were studied: high blood pressure, high cholesterol, diabetes, smoking, and unhealthy body weight.
Read 22 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Mar 31
Lepodisiran — A Long-Duration Small Interfering RNA Targeting Lipoprotein(a): @NEJM #ACC25

🥸This is a great trial

😱 Let's summarize

👇👇👇 Image
🥸1️⃣ Elevated concentrations of lipoprotein(a) are a strong, independent risk factor for cardiovascular disease. Lepodisiran, a long-acting small interfering RNA, targets hepatic production of lipoprotein(a).
🥸2️⃣ In the ALPACA trial, 320 adults with baseline lipoprotein(a) ≥175 nmol/L were randomly assigned to receive lepodisiran (16 mg, 96 mg, or 400 mg) or placebo.
Read 21 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Mar 1
2025 ACC/AHA/ACEP/NAEMSP/SCAI
Guideline for the Management of Patients
With Acute Coronary Syndromes: @CircAHA @JACCJournals

🥸Here are class 1 recommendations from the document; Massive effort - congratulations to the authors: @SVRaoMD

😱 Below

👇👇👇 Image
🥸1️⃣ In patients with suspected ACS, a 12-lead ECG should be acquired and interpreted within 10 minutes of first medical contact to identify patients with STEMI.
🥸2️⃣ In patients with suspected ACS in which the initial ECG is nondiagnostic of STEMI, serial ECGs to detect potential ischemic changes should be performed, especially when clinical suspicion of ACS is high, symptoms are persistent, or the clinical condition deteriorates.
Read 37 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Feb 3
The Physiology of Hunger: @NEJM

🥸 So this is not in CV medicine, but:
(1) it is interesting and (2) it has implications for CV

😱 Good job @NEJM - Summary

👇👇👇 Image
🥸 1️⃣ Hunger is an ancient survival mechanism that evolved to keep humans alive in times of food scarcity.
🥸 2️⃣ Early humans were hunter-gatherers, who faced unpredictable food supplies. Their bodies adapted to store energy efficiently, to help with survival during famine.
Read 21 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Jan 28
Abelacimab versus Rivaroxaban in Patients with Atrial Fibrillation: @NEJM

🥸Summary

👇👇👇 Image
🥸 1️⃣ Abelacimab significantly reduced bleeding in atrial fibrillation patients compared to rivaroxaban, as reported in the AZALEA–TIMI 71 trial.
🥸 2️⃣ Monthly subcutaneous abelacimab achieved a 99% reduction in free factor XI levels at 150 mg and 97% at 90 mg.
Read 21 tweets

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