Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism: @NEJM
🥸 - good work #ACC25 @ACCinTouch
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🥸1️⃣ In cancer-associated VTE, extended anticoagulation is common—but the dose remains uncertain. The API-CAT trial tested reduced-dose vs. full-dose apixaban after 6 months of initial therapy.
🥸2️⃣ 1,766 patients with active cancer and prior VTE were randomized to apixaban 2.5 mg BID or 5 mg BID for 12 months. Median follow-up was nearly 12 months.
Global Effect of Cardiovascular Risk Factors on Lifetime Estimates: @NEJM
🥸 Great work from Germany on global life time risk of CVD risk
😱 Summary
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🥸1️⃣ Lifetime cardiovascular risk increases with the number of classic risk factors you carry at age 50. The Global Cardiovascular Risk Consortium analyzed over 2 million people to estimate how much risk factors shorten life and healthspan.
🥸2️⃣ Five risk factors were studied: high blood pressure, high cholesterol, diabetes, smoking, and unhealthy body weight.
Lepodisiran — A Long-Duration Small Interfering RNA Targeting Lipoprotein(a): @NEJM #ACC25
🥸This is a great trial
😱 Let's summarize
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🥸1️⃣ Elevated concentrations of lipoprotein(a) are a strong, independent risk factor for cardiovascular disease. Lepodisiran, a long-acting small interfering RNA, targets hepatic production of lipoprotein(a).
🥸2️⃣ In the ALPACA trial, 320 adults with baseline lipoprotein(a) ≥175 nmol/L were randomly assigned to receive lepodisiran (16 mg, 96 mg, or 400 mg) or placebo.
2025 ACC/AHA/ACEP/NAEMSP/SCAI
Guideline for the Management of Patients
With Acute Coronary Syndromes: @CircAHA @JACCJournals
🥸Here are class 1 recommendations from the document; Massive effort - congratulations to the authors: @SVRaoMD
😱 Below
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🥸1️⃣ In patients with suspected ACS, a 12-lead ECG should be acquired and interpreted within 10 minutes of first medical contact to identify patients with STEMI.
🥸2️⃣ In patients with suspected ACS in which the initial ECG is nondiagnostic of STEMI, serial ECGs to detect potential ischemic changes should be performed, especially when clinical suspicion of ACS is high, symptoms are persistent, or the clinical condition deteriorates.
🥸 So this is not in CV medicine, but: (1) it is interesting and (2) it has implications for CV
😱 Good job @NEJM - Summary
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🥸 1️⃣ Hunger is an ancient survival mechanism that evolved to keep humans alive in times of food scarcity.
🥸 2️⃣ Early humans were hunter-gatherers, who faced unpredictable food supplies. Their bodies adapted to store energy efficiently, to help with survival during famine.