Impedance and RF ablation:
Part 2: How does RF ablation affect impedance?
1/9 As tissue temperature rises during RF energy application, ions within the tissue being heated become more mobile, resulting in a decrease in impedance to current flow.
2/9 There are currently 2 methods to measure impedance: Generator Impedance (GI) & Local Impedance (LI).
3/9 Lack of impedance drop during RF energy application can reflect inefficient energy delivery to the tissue due to poor tissue contact, lack of catheter stability, or inadequate power delivery.
4/9 LI is measured at the distal electrode of the catheter and represents near-field impedance at the ablation electrode-tissue interface.
5/9 LI drop rate and the magnitude of drop closely correlate to the intra-mural tissue temperature (2-4 mm below the tissue surface) during standard and high-power RF ablation and can thereby act as an intramural thermometer.
6/9 LI drop of 10-20-Ω is observed in clinically effective & safe (intramural temperature 55-90°C) RF applications.
Larger LI drops (>35 Ω) often reflect excessive tissue heating (intramural peak temperature nearing 100°C), indicating a risk for steam pops/char formation.
7/9 LI offers 4-time greater working range than GI, which may permit more precise titration of energy delivery, especially during high-power RF ablation when tissue heating occurs rapidly.
Compared to GI, LI offers more sensitive & more specific measure of intramural tissue heating, as well as larger and more rapid impedance drops during RF application, allowing LI to be used as a real-time monitor of RF lesion formation & to guide titration of RF energy delivery.
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“Aberration” describes transient bundle branch block (BBB) and does not include persistent QRS abnormalities caused by persistent BBB, preexcitation, or the effect of drugs.
Acceleration-dependent BBB (aka “phase 3 block” or “voltage-dependent block”) occurs when an impulse arrives at tissues that are still refractory due to incomplete repolarization (during phase 3 of the action potential [AP]).
3/9
Aberration secondary to phase 3 block tends to be in the form of RBBB when premature excitation (and Ashman phenomenon) occurs during normal baseline heart rates and in the form of LBBB when it occurs during fast heart rates.
Impedance & RF ablation:
Part 1: How does impedance affect RF lesion formation?
1/8 During RF ablation, system impedance = impedance of genera¬tor + transmission lines + catheter + electrode-tissue interface + skin patch interface + interposed tissues.
2/8 IMPEDANCE & POWER
The magnitude of RF current delivered by the generator is determined by impedance btwn ABL electrode and ground pad. Ablation at lower impedance yields higher current output (and tissue heating) compared with ablation at a similar power & higher impedance.
3/8 IMPEDANCE OF ELECTRICAL CONDUCTORS
Currently used electrical conductors from the generator to the patient and from the ground pad back to the generator are designed to have low electrical resistance to help minimize power loss within those conductors.
1/8 ECG patterns that mimic 2°AVB are often related to atrial ectopy, concealed junctional ectopy, or AVN echo beats. Distinguishing physiologic from pathologic AVB is important.
2/8 In 2°AVB, sinus P-P interval is fairly constant (except for some variation caused by ventriculophasic arrhythmia), the nonconducted P wave occurs on time as expected, and P wave morphology is constant. With ectopy, P waves occur prematurely & often have different morphology.
3/8 Early PACs can arrive at the AVN during the refractory period and conduct with long PRI or block (physiologic rather than pathologic block) and can mimic Mobitz I or Mobitz II 2°AVB.
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What Is the Gap Phenomenon? 1/4 “PROXIMAL DELAY ALLOWS DISTAL RECOVERY” is the fundamental concept of gap phenomenon. This requires a distal site with a long effective refractory period (ERP) and a proximal site with a shorter ERP.
2/4 During gap phenomenon, initial block occurs distally (due to longer ERP). Earlier impulses encroach on the relative refractory period (RRP) of proximal site where conduction delay is encountered, which allows for expiration of the ERP of the distal site, enabling conduction.
3/4 Any pair of structures in the AV conduction system that has the appropriate EP physiological relationship can exhibit the gap phenomenon (e.g., atrium–AVN, proximal AVN–distal AVN, AVN–HPS, HB-distal HPS). Gap can occur in the anterograde or retrograde direction.
1/7 Concealed conduction can be defined as "the propagation of an impulse within the conduction system that can be recognized only from its effect on the subsequent impulse, interval, or cycle."
2/7 Impulse propagation in the conduction system generates too small electrical current to be recorded on ECG. If this impulse travels only a limited distance (incomplete penetration) in the conduction system, it can interfere with formation or propagation of another impulse.
3/7 Irregular Ventricular Response During AF:
AVN is expected to conduct at regular intervals when its RP expires after each conducted AF impulse. Irregular response is caused by incomplete penetration of some AF impulses into AVN, variably resetting its refractoriness.
1/9 How reliable is ablation electrode temperature to monitor RF lesion formation?
RF lesion creation is thermally mediated; hence, monitoring tissue temp is the most reliable approach to achieve effective (temp >50°C) & safe (temp <100°C) ablation.
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2/9 Temp measurements relevant to RF lesion formation include:
Directly measuring intramyocardial temp is the optimal method to monitor RF abl, but such technologies are currently not available for clinical use. Investigational technologies: microwave radiometery, US thermal strain imaging, and MR thermometry.