Cog/comp neuro folks: is there a mechanism that an organism can draw on to increase the randomness in the ideas that "occur to it" as possible actions in a given situation?
If an organism is frustrated in its goals or faced with no good options, can it (~choose to) dial up cognitive "exploration" to expand the action search space?
Are any such neural mechanisms known? (e.g., acetylcholine signals of arousal...?) (cc @DrYohanJohn re Grossbergian "arousal" signals)
In a two-stage process, where (i) ideas for what to do are generated ("spring to mind") and (ii) they are evaluated and one is selected, can the variability of step (i) be regulated?
Can the "temperature" be raised so as to help dislodge the system from current attractors and enable exploration of new ones?

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More from @WiringTheBrain

3 Nov
Watching this right now... 🧠👍
Super talks from @mh_lab @neurograce and @TonyZador and superbly chaired by @gsxej! 👏
I did find the idea (from @mh_lab) that some individual *synapses* may be innate and others learned confusing. Does that refer to the existence of the connection or its weight?
Read 5 tweets
18 Oct
Polygenic screening of embryos is here, but is it ethical? theguardian.com/science/2021/o… - great overview by @philipcball; my own thoughts follow...
In my view, polygenic scores are a statistical tool, not one with adequate precision in individuals to warrant use in embryo selection.
It is true that those in the very highest PGS deciles for some complex diseases have significantly higher risk than the population average. But any such embryos will also have sibling embryos with higher than average PGS...
Read 19 tweets
6 Oct
How Mathematical ‘Hocus-Pocus’ Saved Particle Physics quantamagazine.org/how-renormaliz… - on the "renormalization group" as a means of traversing scales...
Question: is renormalization just a handy mathematical tool to enable calculations to be done at higher scales (by truncating sums that tend towards infinity OR= averaging over small-scale parameters at some grid size)?
Or is this how nature itself works? Is there real coarse-graining across levels that grants a degree of genuinely level-specific causality? (Contra reductionism) cc @C4COMPUTATION
Read 6 tweets
28 Sep
I mean, these could be very reliable findings. But they rest on some major assumptions: 1. that psychopathy is at the level of brain a single thing. 2. that the analyses included in the met-analysis are not biased at all...
...and 3. that the size of different brain regions is relatable to (and explains differences in) complex psychological functions like moral reasoning
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23 Sep
How a ‘fatally, tragically flawed’ paradigm has derailed the science of obesity statnews.com/2021/09/13/how… - is obesity due to over-eating or dysregulated fat storage? cc @StephenORahilly
One point not commented on in article is that genes implicated in obesity (through rare or common variants) are enriched for nervous system expression and function...
Do these regulate appetite (many clearly do) or brain mechanisms controlling fat metabolism? Or both?
Read 5 tweets
13 Sep
A little thread on the inevitability of heritability of behavioral or psychological traits 🧵⬇️
Different species of animals - including humans - vary in their innate "natures" (their behavioral and cognitive tendencies and capacities)
These tendencies and capacities are somehow embodied in the structures of their brains and bodies, based on a program encoded in their DNA
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