How a ‘fatally, tragically flawed’ paradigm has derailed the science of obesity statnews.com/2021/09/13/how… - is obesity due to over-eating or dysregulated fat storage? cc @StephenORahilly
One point not commented on in article is that genes implicated in obesity (through rare or common variants) are enriched for nervous system expression and function...
Do these regulate appetite (many clearly do) or brain mechanisms controlling fat metabolism? Or both?
There are all kinds of complicated amplifying feedback loops involved, of course, between fat formation, insulin signaling, and appetite...
One interesting idea from the article is that adipose tissue itself greedily pulls resources from the rest of the body: 
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