A little thread on the inevitability of heritability of behavioral or psychological traits 🧵⬇️
Different species of animals - including humans - vary in their innate "natures" (their behavioral and cognitive tendencies and capacities)
These tendencies and capacities are somehow embodied in the structures of their brains and bodies, based on a program encoded in their DNA
Genetic variation is a fact of life. Errors arise every time eggs and sperm are generated, introducing new genetic variants. Ones that are tolerated survive and accumulate.
The developmental programs in animal genomes have evolved to be robust to such variation, partly by buffering its effects but also by tolerating its effects on resultant phenotypes
Most phenotypic outcomes can vary over a range - bit shorter? bit taller? that's okay, you can still survive. Which is just as well cuz genetic variation can't be avoided and its effects can only be buffered up to a point
So all species accumulate genetic variation that leads to heritable differences between individuals in all kinds of traits (that have a genetically specified species 'norm')
Human psychology is no exception. It is the product of an incredibly complex program in the canonical human genome that specifies a canonical human brain
Except no individual has the 'canonical' human genome or brain - we all have inevitable variations in our genomes and *consequent variations* in our brains and our psychological traits
If human nature is encoded in our DNA generally, there is no way such individual variation could not also occur. It is the flip side of the same coin.
And if genetic differences make people psychologically different from each other, then related people (like twins or family members) will be more similar to each other
Which is exactly what decades of twin and family studies find and (controlling for shared environments) why they can be used to estimate the "heritability" of such traits
So, even with all the possible methodological quibbles with particular study designs, the fundamental observation - that genetic differences affect our individual natures - is completely expected. It couldn't be otherwise.

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More from @WiringTheBrain

12 Sep
Kathryn Paige Harden: ‘Studies have found genetic variants that correlate with going further in school’ theguardian.com/science/2021/s… - tricky stuff here...
It should be no surprise to anyone that children differ in ways that affect (not determine, but contribute to) how far they go in education.
Some of those differences are genetic in origin, others may be the result of variation in brain development (explaining why even identical twins may differ)
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19 Jul
Reading here about Higher-Order Thought (HOT) theories of consciousness, which make a lot of sense to me: plato.stanford.edu/entries/consci…
Basic idea is that conscious awareness (of a percept or an intention) requires a secondary representation - the recognition that you are having that percept or intention
That all fits with lots of neural and neurological findings, though there are many possible criticisms of this framework...
Read 6 tweets
11 Jun
This book is brilliant. Incredibly precise exposition of how reasons - grounded in beliefs, desires, and knowledge - drive behavior Image
This is the kind of philosophy I really enjoy. No outlandish thought experiments, no semantic sleight-of-hand, no clever moves aimed to stump opponents... Just clear, rigorous analysis
One key insight: the distinction between a triggering cause (stimulus A -> action/outcome B) and a structuring cause (the reason *why* A->B)
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23 May
Really excellent, insightful article highlighting crucial role of culture in understanding variation in heritability 👇 But I have a quibble... (thread below)
The article frames phenotypic variance as capable of being partitioned into a component explained by genetic variance and a component explained by environmental variance. 2/n
And it looks in detail at how environmental variance and gene-environment interactions (and therefore heritability) are all sensitive to cultural differences, clustering, sampling effects, etc. 3/n
Read 16 tweets
21 Mar
I think @Lise_Eliot and colleagues have done a real service to the field in performing this exhaustive meta-analysis of the messy literature on sex differences assessed by neuroimaging cc @bogglerapture @StuartJRitchie
Longish thread: *Assessed by neuroimaging* is important here, as it’s an extremely gross level at which to look for differences, compared to what can be done in other animals (where lots of fine differences are observed).
So there could, in the first instance, be NO sex differences observed by neuroimaging and that would not have any bearing on whether differences exist in microarchitecture, distribution of cell types, synaptic connectivity, gene expression profiles, cellular physiology, etc.
Read 20 tweets
23 Aug 20
Towards Reproducible Brain-Wide Association Studies biorxiv.org/content/10.110… (thread follows...👇)
This is a really interesting and important paper showing that very large samples are required to get reliable associations between brain imaging and behavioral phenotypes
The starkest conclusion is that the vast sea of literature to date claiming such associations is completely polluted by false positives (not a surprise given they never replicate)
Read 15 tweets

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