Just published @ScienceMagazine
The remarkably tight correlation of neutralizing antibody levels with protection from an mRNA vaccine (@moderna_tx)
Titer/Vacccine efficacy
These are important data, fully concordant with 2 recent studies, reinforcing why boosters are essential and why it is likely that a 3rd dose will be long lasting (1 year or longer)
@LancetMicrobe all vaccines, all variants
A 25-50 fold increase in levels of neutralizing antibody of the booster (3rd dose) compared with the 2nd, and more rapidly generated
Another Figure from the @LanctMicrobe paper that tells this story

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More from @EricTopol

24 Nov
Our oped on the big mistake @CDCgov on boosters: All adults, not just age 50 plus, need them. Here's why
@washingtonpost @mtosterholm
washingtonpost.com/opinions/2021/… @PostOpinions
Now is not the time to withhold a vital and validated means of boosting our efforts to contain the virus
Each day in the United States, the number of people with waning immunity greatly exceeds those who are getting newly vaccinated. Accordingly, rather than building our wall of population immunity, the United States is suffering attrition.
Read 4 tweets
24 Nov
The UK's path towards improvement as much of Europe is worsening
1. Boosters (3rd shots) are working, as seen by fewer hospital admissions among the age groups receiving them
2. Infection-acquired immunity playing a role
3, Comparison with many countries throughout Europe experiencing a rapid rise in cases, patients requiring ICU admission and deaths
Read 4 tweets
20 Nov
The United States is not taking its 5th major wave seriously.
In November, new cases have increased 30% starting from the high level of 70,000/day. With that hospitalizations and deaths are increasing again.
We haven't taken heed from Europe 4 times
theguardian.com/commentisfree/… /1
Our vaccination rate is dangerously low, putting >100 million Americans (40% of 331 M) who are not vaccinated vulnerable. Then there's another 40% who were highly 💉💉protected, but are now out 6 months out and that protection has waned /2
Instead of @CDCgov urging all people who've waned to get a 3rd shot, they deemed them "eligible." Only age 50+ "should" according to their recommendation. That is *not* what the data show and will further diminish our immunity wall /3
Read 8 tweets
19 Nov
First look at the only randomized trial of a booster vaccine data (Pfizer) today cdc.gov/vaccines/acip/…
95% efficacy vs symptomatic infections, consistent across all age, sex, race, ethnicity and comorbid condition subgroups
Benefit seen very early
Primary efficacy endpoint: 6 (booster) vs 123 events (placebo)
Solid safety profile
Side by side event curves for the original Pfizer vaccine trial vs the Booster trial
You can see the curves diverge about a week earlier with a booster, ~14 vs 7 days, which aligns with much faster induction of neutralizing antibodies
Read 6 tweets
16 Nov
The problem with vaccine waning 4-6 months later was 1st recognized in Israel in July, confirmed by more than 10 reports, and occurs with all vaccines. Protection is fully restored (or even exceeded) by 3rd (booster) shots.
The >95% vaccine efficacy vs hospitalizations and deaths for mRNA vaccines in the Phase 3 randomized trials also waned. Protection is fully restored to this high level by 3rd (booster) shots.
How long will it last?
Nobody knows for sure yet.
But let's hope Israel is right again:
"By analyzing the antibody levels, researchers have concluded that the third shot could be effective for 9 – 10 months, or even longer."
Read 5 tweets
14 Nov
Addressing the anti-vaxxer BS about vaccines not preventing transmission. It's not 0|1.
1. Recent Dutch study during Delta
"Effectiveness of full vaccination of the index against transmission to unvaccinated household contacts was 63% (95%CI 46-75%)."
2. UK study with Delta by genome sequencing, household transmission reduced from 38% (via unvaxxed) to 25% (vaxxed), a 35% reduction
3. A 2nd UK study with sequencing of Delta showed a 27% reduction of transmission for vaccinated vs unvaccinated
Read 4 tweets

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