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Eric Topol Profile picture
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14 Nov, 4 tweets, 2 min read
Addressing the anti-vaxxer BS about vaccines not preventing transmission. It's not 0|1.
1. Recent Dutch study during Delta
"Effectiveness of full vaccination of the index against transmission to unvaccinated household contacts was 63% (95%CI 46-75%)."
medrxiv.org/content/10.110…
2. UK study with Delta by genome sequencing, household transmission reduced from 38% (via unvaxxed) to 25% (vaxxed), a 35% reduction
thelancet.com/journals/lanin…
3. A 2nd UK study with sequencing of Delta showed a 27% reduction of transmission for vaccinated vs unvaccinated
thelancet.com/action/showPdf…
4. Fully vaccinated status reduces Delta transmission. With Delta for HOUSEHOLD CONTACTS, the worst case scenario, that reduction range from 27-63% in these studies. 💉💉Transmission reduction outside of households is likely considerably higher but difficult to quantify.

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More from @EricTopol

Eric Topol Profile picture
13 Nov
Why should every adult get a 3rd shot (booster) when eligible (6 months after 1°💉)?
1. A randomized, placebo-controlled trial, the gold standard for assessing efficacy, showed restoration of efficacy to 95.6%, in >10,000 participants across all age groups
2. Prevention of hospitalizations and deaths in a study of >728,000 people w/ 3-shots vs >728,000 matched controls (2-shots) thelancet.com/journals/lance… @TheLancet ImageImage
3. We have no US National data by vaxx status but hospitalizations are starting to increase again and several states are reporting an increasing proportion of breakthroughs accounting for them Image
Read 8 tweets
Eric Topol Profile picture
11 Nov
The @nytimes published "What We Know So Far About
Waning Vaccine Effectiveness" today
It is misleading and missing key reports from New York State, Veterans Affairs, Puerto Rico, Israel, Qatar, the UK, and several others
nytimes.com/interactive/20…
Exemplifies bad messaging, skewed, incomplete data.
No, it's not true that "vaccines still offer strong protection against severe Covid-19" which is why the majority of at-risk US people (such as age 60+, past 6 months from 💉💉) have not gotten boosters yet
For months the media & many experts insisted the vaccines were fully protective vs severe disease while the evidence was pointing against that assertion. Still today @nytimes! No wonder the public is confused and booster uptake is low. Only 32% in the highest risk age group, 65+
Read 4 tweets
Eric Topol Profile picture
9 Nov
Important new study on immunity (anti-spike Ab) waning and breakthrough infections after AZ & Pfizer vaccines in >5500 people
1. AZ far more pronounced and earlier waning than Pfizer & more breakthroughs
2.Anti-S correlated w/ risk of breakthroughs
medrxiv.org/content/10.110… ImageImage
"Our data demonstrate the importance of booster doses to maintain protection in the elderly and clinically vulnerable and suggest that these should be prioritized to those who received ChAdOx1 [AZ vaccine] as their primary course."
About timing:
"Our results show waning to levels associated with breakthrough infections before this 6 month period for those vaccinated with ChAdOx1 but not for BNT162b2."
Read 4 tweets
Eric Topol Profile picture
5 Nov
My summary table comparing the new and highly effective anti-Covid pills, a vital step forward for prevailing over the pandemic
No head-to-head trial to know about true comparative efficacy, but key differences in mechanism and other features
So well done on this by @Dereklowe
science.org/content/blog-p…
Read 4 tweets
Eric Topol Profile picture
3 Nov
The next chapter of anti-Covid is about to start with pills that inactivate the virus, irrespective of variants. First will be Molnupiravir in a matter of weeks, then this one.
Helping to get us onto an exit ramp. science.org/doi/10.1126/sc…
@ScienceMagazine
These will add an important new layer of defense early after symptom onset w/ test positive confirmation and also, as clinical trials get completed, for known exposure
Success of the Covid pill era depends on rapid tests that are widely available, free or very inexpensive, and accurate. While the pills are coming soon, the US is still woefully unprepared for their roll out.
Read 4 tweets
Eric Topol Profile picture
30 Oct
There's currently one continental outlier: Europe
@OurWorldInData
The top 10 countries for covid cases/capital globally are all in Eastern Europe
While there has been an increase in cases in several Western European countries, it is small (per capita) relative to the previous group
Read 4 tweets

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