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Chise Profile picture
@sailorrooscout
Nov 26, 2021 • 20 tweets • 8 min read • Read on X
If there is one thing I am going to tell you today it is to IGNORE the media and the clickbait headlines on this new variant. There is NO plausible scenario this will take us back to square one and there is a lot of misinformation currently circulating. Working on a thread now.
Just a friendly reminder. Despite what you might hear, there has yet to be a variant that isn’t susceptible to the vaccines.

Let’s talk about Nu (B.1.1.529) clear up some misconceptions, and talk about why it is unlikely it will evade vaccine-induced immunity. 🧵
Why are variants unlikely to FULLY evade vaccine-induced immunity?
•Vaccines are POLYCLONAL
•CD8+ T-cells covering 52 epitopes across the spike protein
•CD4+ T-cells covering 23 epitopes across the spike protein
For more on this see: science.org/doi/10.1126/sc… ImageImageImageImage
So, let’s get a couple of things straight NO ONE knows if it is more transmissible at this point. Seeing “Nu is 500% more transmissible” with no data and maybe a bad interpretation of a graph? Yeah, someone is yanking your chain. Also it is NOT a new virus, it is A VARIANT of the
same SARS-COV-2 virus we have been dealing with for almost 2 years now. Stop that. Give me a break. To those saying it is “outcompeting” Delta. Important thing to keep in mind: there hasn’t been much Delta to displace or “outcompete.” Until last week, South Africa was at its
lowest incidence rate since the beginning of the pandemic. In other words, the low incidence of Delta in South Africa kinda means that Nu becoming dominant is weaker evidence of it “outcompeting” it when there really wasn’t much to outcompete so to speak.
You can see for yourself here. With relatively low cases, this may left a void which a new variant could spread into more easily- it likely hasn't had to compete with Delta and in other countries where Delta rages on, it very well may not be as fit. ImageImage
Secondly, we can’t predict virus behavior in its entirety from mutations. Yes, I know the number of mutations is off-putting BUT more mutations ≠ BAD. We have seen other alarming variants that have failed to spread as widely in the past.
Next, I want everyone to know this now, we don’t know if there are other factors that may be helping this to spread. South Africa has a LOW VACCINATION RATE. We are talking about 24% FULLY VACCINATED and this DESPERATELY needs to be fixed.
Vaccine equity is vital. Variants pop up out of low vaccinated areas. Immune evasion may not be needed to spread and fitness could EASILY differ in higher-vaccinated countries, and those dominated by Delta. I also recommend reading this thread here: Image
In regards to those who were infected with Nu, some data has come out regarding the status of some individuals, specifically out of Hong Kong. Vaccinated fully with Pfizer back in May/June, the individual is currently ASYMPTOMATIC. You can read more here:
So, what data DO we have? From this extremely informative thread from it is likely we WILL NOT see Nu FULLY escape vaccine-elicited antibodies, and therefore likely little issues with severe disease. Which IS encouraging. READ THIS: Image
These vaccines are polyclonal, there are non-neutralizing antibodies, and T-CELLS. Will the vaccines take a hit? Likely. as they do with ALL variants. Will it completely render these useless? Absolutely not. For those saying Nu decimates these vaccines to 30% efficacy? Stop that.
TLDR: YES, we need more data. NO, we are NOT going back to square one. The BEST thing you can do right is to GET VACCINATED. GET THE WORLD VACCINATED. GET BOOSTED, it not only restores it EXCEEDS. It is time we stop tripping up over our own feet. This DOESN’T need to be so hard. Image
Angelique Coetzee, chairperson of the South African Medical Association: “It’s all speculation at this stage. It may be it’s highly transmissible but so far the cases we are seeing are EXTREMELY MILD.” theguardian.com/world/2021/nov…
Update on the case in Belgium. Unvaccinated and developed flu-like symptoms after being infected with Nu but NO WORSE symptoms 11 days after returning from Egypt. NO other symptomatic individuals in their household. assets.uzleuven.be/files/2021-11/… Image
Minister of Health of South Africa: There is NO EVIDENCE that the Nu variant evades our current vaccines.
Mathivha was VERY careful to describe "partially vaccinated" as those with just ONE dose of mRNA. Even without a booster, 0% of those currently hospitalized are FULLY vaccinated (two doses of mRNA). This is VERY encouraging. The vaccines ARE working.
Yes, I am aware they have changed it to Omicron from Nu. This thread was written before that announcement. Just know this entire thread is in regards to Omicron (B.1.1.529).
South Africa's Health Minister says, based on a small sample of Omicron cases, the majority of hospital patients are unvaccinated: "It indicates that the vaccines ARE providing protection.” . Let’s stay calm but vigilant. businessinsider.com/omicron-corona… Image

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More from @sailorrooscout

Chise Profile picture
Jun 27
THIS IS HUGE! Researchers at JHU have identified the Aplp1 protein, which facilitates the spread of harmful alpha-synuclein proteins in the brain as a novel therapeutic target for Parkinson’s disease AND a potential therapy using an EXISTING FDA-approved cancer drug.🧵⬇️
Source:
•
• link.springer.com/article/10.103…
hopkinsmedicine.org/news/newsroom/…

Summary: Researchers discovered a novel therapeutic target for Parkinson’s disease, the Aplp1 protein, which facilitates the spread of harmful alpha-synuclein proteins in the brain. Notably, an FDA-approved cancer drug targeting Lag3- a protein that interacts with Aplp1- has shown promise in blocking this spread in mouse models. This breakthrough research suggests the potential for repurposing existing cancer therapies for Parkinson’s disease and other neurodegenerative conditions.
Key Facts: •Aplp1 and Lag3 interaction is crucial for the spread of alpha-synuclein in the brain. •A FDA-approved cancer drug, nivolumab/relatlimab, targeting Lag3 shows potential in blocking this interaction. •This research offers new hope for the treatment of Parkinson’s and other neurodegenerative diseases.
In studies with genetically engineered mice, Johns Hopkins Medicine researchers say they have identified a potentially new biological target involving Aplp1, a cell surface protein that drives the spread of Parkinson’s disease-causing alpha-synuclein.
Read 15 tweets
Chise Profile picture
Jun 21
THIS IS HUGE! For the FIRST time, an HIV PrEP drug candidate in the form of a twice-yearly subcutaneous shot has shown ZERO infections in a late-stage Phase III trial. Lenacapavir was 100% effective at preventing HIV in MORE THAN 2,000 participants.

Let’s talk about that!🧵⬇️
Source:
• gilead.com/news-and-press…
KEY POINTS •Gilead’s twice-yearly medicine to prevent HIV succeeded in a Phase 3 trial. •None of the roughly 2,000 women in the trial who received the lenacapavir shot contracted HIV. •Gilead needs to replicate the results in another Phase 3 trial before seeking FDA approval. The company expects to share more data later this year or early next year. •If the results are positive, Lenacapavir for PrEP could reach the market as soon as LATE 2025.
These results come from the PURPOSE 1 trial evaluating Gilead Sciences’ twice-yearly, subcutaneous Lenacapavir in women and adolescent girls ages 16 to 25 in South Africa and Uganda. Lenacapavir, which is a capsid inhibitor, is already approved by the FDA under the
Read 14 tweets
Chise Profile picture
Jun 11
THIS IS HUGE! Researchers at the University of Illinois have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections (MORE THAN 130 multidrug-resistant bacterial strains, in fact) while sparing the gut microbiome!

Let’s talk about that!🧵⬇️
The findings were recently published in Nature.
•

The study looked at the development of an antibiotic that targets gram-negative bacteria without disturbing the gut microbiome.nature.com/articles/s4158…
Researchers identified the antibiotic lolamicin, which disrupts a particular system called the Lol lipoprotein transport system.
•ncbi.nlm.nih.gov/pmc/articles/P…
Read 13 tweets
Chise Profile picture
Jun 7
THIS IS HUGE! A major trigger in inflammatory bowel disease (IBD) and related conditions has been identified, and existing drugs CAN stamp it out, in what scientists call a "massive step" in successfully treating these debilitating chronic conditions. Let’s talk about that! 🧵⬇️
Researchers at the Francis Crick Institute, in collaboration with University College London (UCL) and Imperial College London (ICL), have uncovered a problem gene enhancer that stimulates action along a specific biological pathway that causes IBD inflammation.
Until now, our incomplete knowledge of what drives IBD has made it incredibly hard to find a 'one-size-fits-all' medical intervention.

The findings were published recently in Nature.
•nature.com/articles/s4158…
Read 15 tweets
Chise Profile picture
May 28
HOW COOL IS THIS? A vaccine for honeybees? More likely than you think! Not only did the vaccine protect bees from a fatal BACTERIAL disease, it ALSO protected them against from a VIRAL disease spread by varroa mites! Now that’s a BUZZWORTHY solution! 🐝

Let’s talk about that! 🧵 Honeybees are under stress from pesticides, mites and a variety of diseases. Now, a new vaccine aimed at protecting bees from a serious bacterial infection may do double duty by warding off a virus.
The first vaccine designed for insects may make honeybees healthier overall. Honeybee hives vaccinated against a bacterial disease had much lower levels of an unrelated viral disease than did unvaccinated hives.
•frontiersin.org/articles/10.33…
Researchers at Dalan, based in Athens, Georgia designed the bee vaccine to protect against American foulbrood- a fatal disease caused by a spore-forming bacterium called Paenibacillus larvae. Adult bees don’t get sick but can spread spores in the hive, where the disease infects
Read 13 tweets
Chise Profile picture
May 22
THIS IS HUGE! A new study shows nanoparticles fashioned from the cowpea mosaic virus demonstrated remarkable success in improving survival rates AND suppressing the growth of metastatic tumors across VARIOUS cancer models including colon, ovarian, and breast cancer!🧵⬇️
An experimental treatment made from a plant virus is effective at protecting against a broad range of metastatic cancers in mice, shows a new study from the University of California San Diego.

The findings were published recently in Advanced Science.
•onlinelibrary.wiley.com/doi/10.1002/ad…
The treatment, composed of nanoparticles fashioned from the cowpea mosaic virus showed remarkable success in improving survival rates and suppressing the growth of metastatic tumors across various cancer models. Similar outcomes were also observed by the team when the treatment
Read 11 tweets

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