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Saad Z. Usmani MD MBA FACP (he/his/him) Profile picture
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4 Dec, 7 tweets, 9 min read
1/For this #ASH21 'Best of Abstracts' selection, I asked my @sloan_kettering #mmsm service team members for top 5 abstracts in different categories. Please follow the thread below for the #ASH21_MSKMM selections:
2/Top 5 Basic/Translational
-ash.confex.com/ash/2021/webpr…
- ash.confex.com/ash/2021/webpr…
- ash.confex.com/ash/2021/webpr…
- ash.confex.com/ash/2021/webpr…
3/Top 5 MGUS/SMM
- ash.confex.com/ash/2021/webpr…
- ash.confex.com/ash/2021/webpr…
- ash.confex.com/ash/2021/webpr…
- ash.confex.com/ash/2021/webpr…
- ash.confex.com/ash/2021/webpr…
4/Top 5 NDMM
- ash.confex.com/ash/2021/webpr…
- ash.confex.com/ash/2021/webpr…
- ash.confex.com/ash/2021/webpr…
- ash.confex.com/ash/2021/webpr…
- ash.confex.com/ash/2021/webpr…
5/Top 5 RRMM
- ash.confex.com/ash/2021/webpr…
- ash.confex.com/ash/2021/webpr…
- ash.confex.com/ash/2021/webpr…
- ash.confex.com/ash/2021/webpr…
- ash.confex.com/ash/2021/webpr…
6/Honorable Mentions
- ash.confex.com/ash/2021/webpr…
- ash.confex.com/ash/2021/webpr…
- ash.confex.com/ash/2021/webpr…
7/ Follow us along during #ASH21 #ASH21_MSKMM for comments on different abstract! #MedTwitter @kordeneha1 @LesokhinMD @UrviShahMD @CarlynRTanMD @MalinHultcrantz Drs. Hassoun, Malilankody & Maclachlan not on twitter @sloan_kettering @ASH_hematology @HemOncFellows

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More from @szusmani

Saad Z. Usmani MD MBA FACP (he/his/him) Profile picture
9 Nov 20
1/7 Lots to unroll on #ASH20SU #ASH20 #mmsm abstracts, will do in several categories:

TOP TRANSLATIONAL
-ImmunoCell Study (ash.confex.com/ash/2020/webpr…)
-Discordance btwn IFE and MRD (ash.confex.com/ash/2020/webpr…)
@theMMRF @IMFmyeloma @Myeloma_Society @ASH_hematology
2/7 #ASH20SU #ASH20 #mmsm
-Immune ME Changes from MGUS/SMM to active MM (ash.confex.com/ash/2020/webpr…)
-PCL Genome/Transcriptome (ash.confex.com/ash/2020/webpr…)
-Resistance to BCMA Therapy (ash.confex.com/ash/2020/webpr…)
-Immunogenomic heterogeneity in MM (ash.confex.com/ash/2020/webpr…)
3/7
 TOP CLINICAL NON-CART PHASE 1 RRMM #ASH20SU #ASH20 #mmsm
-Teclistamab (ash.confex.com/ash/2020/webpr…)
-MEDI2228 (ash.confex.com/ash/2020/webpr…)
-Talquetamab (ash.confex.com/ash/2020/webpr…)
-BFCR4350A (ash.confex.com/ash/2020/webpr…)
-TNB-383B (ash.confex.com/ash/2020/webpr…)
Read 7 tweets
Saad Z. Usmani MD MBA FACP (he/his/him) Profile picture
10 Sep 20
The chromosome 1q21 story (1/10):
-Having extra copies of generally odd num. chromosomes constituents hyperdiploidy #mmsm , recognized as ‘HY’ in GEP based molecular classification.
-Having 3 copies is called ‘gain 1q21’
-Having >=4 copies is called ‘amplification of 1q21’.
The chromosome 1q21 story (2/10):
-Herve Avet-Louiseau identifies 1q21 ‘enhancement’ in human MM cell lines, primary MM cells and plasma cell leukemia (PMID: 9172003), Shaughnessy et al corroborate (PMID: 15472896).
- Gain/Amp ch. 1q21 first recognized as poor prognostic markers
The chromosome 1q21 story (3/10):
...in MM by Arkansas group in mid-2000s (PMID: 16188652, PMID: 16705089)
- Corroborated by other groups (PMID: 16995883, PMID: 17024118, PMID: 20537706, PMID: 21523726) in the context of pre-novel and doublet novel induction/transplant era.
Read 10 tweets

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