Thread by @Grimhood

Lysgergic acid diethylamide (LSD) is technically semi-synthetic, the OG “research chemical”.

https://twitter.com/jakexbrann/status/1467400504237957120

Both the chemical structure, pharmacology, and experience itself of LSD, as a lysgeramide, and psilocybin, as a tryptamine and betacarboline combination, differs quite significantly despite both being of the psychedelic entheogen classes.

In my opinion, they can’t really be compared.

I’ve always said, LSD is like being in the drivers seat of the consciousness, while psilocybin is like being passenger.

What I mean by this is LSD lacks the plant/fungus spirit that organic psychedelic entheogens possess, such as psilocybin, ayahuasca, and mescaline-containing cacti.

With LSD, you are left to your own mind without guidance of these ancient spirits.

While technically being neurotrophic, I do not believe it possesses the same potential of Neurogenesis as tryptamines and phenyethylamines do.

This is primarily because of its potent dopaminergic activity and resulting neurotransmitter waste metabolite production.

It’s pharmacology and effects are akin to methamphetamine until you consume high doses, without the severe neurotoxicity. I do believe it comes with its own detriments for this reason, being inflammatory after the experience is said and done.

It is often draining the higher dosage you consume for this reason, whereas tryptamines will often possess an “afterglow”.

You are left to your own accord, and I believe it is more suited to reflection, introspection, connection to Source/God (depending on dosage), perspective shift, and recreation.

Tryptamines have a more lasting benefit in the fact that it’s neurotrophic properties create lasting changes in the brain and the connection to Source/God is more pronounced.

Without the spirit connection, LSD often makes you feel more alone in the universe. It’s a very selfish experience, for lack of better words.

Because of this, you are forced to learn from the experience on your own and take from it what you will, whereas tryptamines and phenylethylamines will “show” you what you are meant to learn, forcefully or not.

The messages you learn are often different because of this.

This is speaking from thousands of experiences with LSD, psilocybin, psilohuasca, DMT, ayahuasca, mescaline containing cacti, betacarbolines, and research chemicals under my belt. Your opinion may be different.