Mechanism behind thiamine's unique ability to reverse disease (even without a deficiency):
- Oxidative stress, inflammation, and toxins inactivate our cell machinery used to generate energy
- Sustained mega doses of B1 can re-activate these enzymes, restoring energy & function
- Oxidative stress, inflammation, and toxins inactivate our cell machinery used to generate energy
- Sustained mega doses of B1 can re-activate these enzymes, restoring energy & function
The thiamine-dependent enzyme a-KGDH is extremely sensitive to oxidative stress and toxicity.
This is a RATE-LIMITING enzyme. When it becomes inactivated, mitochondrial energy metabolism shuts down.
This enzyme is decreased in a variety of neuro-degenerative conditions
This is a RATE-LIMITING enzyme. When it becomes inactivated, mitochondrial energy metabolism shuts down.
This enzyme is decreased in a variety of neuro-degenerative conditions
Pharmacological doses of thiamine can "saturate" the enzyme, forcing it to start working and overcome the inactivation caused by toxins/oxidative stress/inflammation.
In this way, thiamine is being used pharmacologically.
Dietary thiamine cannot achieve this effect
In this way, thiamine is being used pharmacologically.
Dietary thiamine cannot achieve this effect
Because of this, thiamine can be used in practically ANY condition which involves mitochondrial dysfunction.
So, mega-dosing is not merely addressing a deficiency.
It means that thiamine can be medicinal even when there is no actual deficiency present.
So, mega-dosing is not merely addressing a deficiency.
It means that thiamine can be medicinal even when there is no actual deficiency present.
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