A recently developed method, that expresses full spike trimers, enables more accurate measurement of binding IgG1 antibodies. Quite a few interesting results in this study.
First of all, the second dose of mRNA vaccines adds very little extra binding. medrxiv.org/content/10.110…
First of all, the second dose of mRNA vaccines adds very little extra binding. medrxiv.org/content/10.110…
More importantly, the absolute increase in Delta variant binding antibodies following administration of the 2nd dose to previously infected people is limited to a small subset of adults. At the same time, the relative number of Delta binding Ab to non-binding (old Wuhan) Ab is…
…terribly low. What’s the use of that thick soup of sky high antibodies then? Triggering autoimmunity? 🤔
The authors are not impressed either, although expected such results from shotgun injecting the same antigen, leaving no time for maturation.
The authors are not impressed either, although expected such results from shotgun injecting the same antigen, leaving no time for maturation.
https://twitter.com/gerdosi/status/1351970951819382785
So what do these results suggest? The authors’ takeaway clearly is that adding a third dose of the same vaccine could be counterproductive in the vast majority of recipients, except for the immunocompromised who failed to mount a proper response to the first pair of doses.
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