Arnav Agarwal Profile picture
Dec 7, 2021 9 tweets 13 min read Read on X
🔊Our latest @WHO living guidance on treatments for #COVID19, out today:

For severe/critical:
✅steroids
✅IL-6 RB
🟨mAb
🟧convalescent plasma🔥

For non-severe:
🟨mAb
🟧steroids
🚫convalescent plasma🔥

For both:
🟧remdesivir
🟧ivermectin
🚫HCQ
🚫LPV/r

bit.ly/3pAK6Oe ImageImage
Two recommendations:
🌟against administering convalescent plasma for non-severe covid-19.
🌟against administering convalescent plasma for severe or critical covid-19, except in the context of a clinical trial. Image
A living systematic review & network meta-analysis, led by @RSiemieniuk & @rominabrigpet with contributions from @jessbartoszko, @DenaZera, @AnilaQasim, @Elena_Kum et al, informed recommendations.

Now with a 🔥🔥 website with evidence readily accessible: covid19lnma.com. Image
🌟For non-severe illness:
- No benefit for critical or important outcomes, including mortality and mechanical ventilation
- Potential for harm
- Resource requirements / practical issues (donor identification & testing, plasma collection / storage / transportation, administration) ImageImageImage
🌟For severe/critical illness:
- Low certainty evidence for mortality, mechanical ventilation, etc.
- Potential for harm.
- Resource requirements (similar issues, though may be easier to administer in hospitalized patients).
- More research needed to reduce uncertainty. ImageImageImage
This work contributes to collaborative living guidance produced by @WHO and the #MAGIC Evidence Ecosystem on drugs to prevent #COVID19, also published via @bmj_latest.

This is an incredible cross-collaborative effort - honoured and lucky to be part of it.
Associated guideline in the @WHO portal: bit.ly/3ExWeG3

Associated guideline in @theMAGICapp:
bit.ly/3Gk5ldZ

Associated LNMA: bit.ly/3lIKNnP Image

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More from @ArnavAgarwalMD

Mar 3, 2022
🔥 Our latest @WHO living guidance on drugs for #COVID19:

Severe/critical:
✅steroids, IL-6RB, baricitinib
🔷REGN-COV
🔶other JAK2i, plasma

Non-severe:
🔷molnupiravir, REGN-COV, sotrovimab
🔶steroids
🚫plasma

All:
🔶remdesivir, ivermectin
🚫HCQ, LPV/r

bit.ly/3pAK6Oe
Important considerations/caveats:
✨Choice between baricitinib & IL-6RB for severe/critical COVID-19 depends on availability & clinical/contextual factors.
✨In non-severe illness, molnupiravir, sotrivimab & casirivimab-imdevimab are weakly recommended for those at highest risk.
Some other considerations/caveats:
✨Other JAK2i should be considered for severe/critical illness only if baricitinib is not available.
✨Ivermectin (across severities) & plasma (for severe/critical) should be considered only in the context of a clinical trial.
Read 13 tweets

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