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Eric Topol Profile picture
@EricTopol
Dec 9, 2021 • 5 tweets • 3 min read • Read on X
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The overwhelming evidence for 3rd shot boosters *before* Omicron, reinforced by new data for benefit vs Omicron
1. The randomized trial of 3 shots vs 2 shots + placebo, 95% efficacy for preventing symptomatic infections across all age 16+ groups (N=10,125)
cdc.gov/vaccines/acip/…
2. Reduction in death by 90% for age 50+, 3 shots vs 2, among >840,000 people
nejm.org/doi/full/10.10… @NEJM
3. Marked reduction of hospitalizations and deaths in over 728,321 people with 3 shots vs matched 728,321 people with 2 shots, across all age groups
thelancet.com/action/showPdf…
4. Now vs Omicron, the variant with substantial immune escape, the 3rd shot induced a 25-fold increase in neutralizing antibody titer pfizer.com/news/press-rel…
Clinical correlation with effectiveness data and duration of impact pending
PS I am getting very tired of people ("experts," CDC, journalists) negating the incontrovertible evidence for 3rd shots that existed prior to Omicron, which is one of the reasons why less than 1 in 4 US adults have had boosters

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More from @EricTopol

Eric Topol Profile picture
Apr 13
Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is favorably affected by exercise and likely many other lifestyle factors.
Here’s (almost) everything we know about it. In Ground Truths (link in my profile d/t X-suppression)Image
Here's the response to exercise Image
The most sensitive and accurate biomarker to date Image
Read 5 tweets
Eric Topol Profile picture
Apr 5
A major @Nature paper this week found a significant decline in dementia after an outdated Shingles vaccine.
I've reviewed the study and many other relevant ones in a new Ground Truths (link in profile) Image
A Table from the post Image
The effect in the 2 natural experiments differed substantially by sex with the benefit predominant in women Image
Read 5 tweets
Eric Topol Profile picture
Apr 2
The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence
"implications are profound"
New @Nature
nature.com/articles/s4158…
nature.com/articles/d4158…
Accompanying @NatureNV nature.com/articles/d4158…
Read 4 tweets
Eric Topol Profile picture
Mar 24
Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome🧵 @NatureMedicine Image
These are the specific foods that were linked with healthy aging and other outcomes. Green-favorable; Red-unfavorable Image
Adherence to these diets (most to least in quintiles) linked to healthy aging Image
Read 4 tweets
Eric Topol Profile picture
Feb 3
A paper on microplastics accumulating in the brain was just published @NatureMedicine, open-access
I review the background and major implications in a new Ground Truths edition (link in my profile)nature.com/articles/s4159…Image
Image
The human brain:
—had 7-30 times more accumulation of microparticles (MPs) than the liver or kidney (organs with previously documented high propensity)
—from people with dementia had 5X accumulation of MPs compared with non-dementia
—there was a marked increase of accumulation over recent years
Your Health Alert washingtonpost.com/climate-enviro…Image
Read 4 tweets
Eric Topol Profile picture
Dec 31, 2024
Three new @NEJM reports on #H5N1 today
1. An overview by @MichaelGIsonMD and @DrJeanneM
"urgent need for vigilant surveillance of emerging mutations and assessment of the threat of human-to-human transmission" Image
Image
2. Report of the 13-year-old Canadian girl who developed acute respiratory failure. Sequence of her H5N1 revealed 3 mutations that may be linked to higher virulence and adaptation to human cell binding Image
Image
3. Review of 46 cases of mild H5N1 illness by CDC in 2024 Image
Read 6 tweets

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