blinki.st/c87019b62fd6?b…
Today's free blinks are on the Epigenetics Revolution (2011) by @NessaCarey
Today's free blinks are on the Epigenetics Revolution (2011) by @NessaCarey
blinki.st/c87019b62fd6?b…
The human genome project was published in Jun 2000.
I was a final year medical student back then and have vague memories of the announcement in the news.
Epigenetics involves the switching on and off of various genes.
The human genome project was published in Jun 2000.
I was a final year medical student back then and have vague memories of the announcement in the news.
Epigenetics involves the switching on and off of various genes.
blinki.st/c87019b62fd6?b…
"We overestimated the importance of DNA".
I like Carey's metaphor of DNA being like a script for a play. There is considerable room for variation and improvisation - that's the epigenetics. Genotype is the DNA, phenotype is the epigenetic expression.
"We overestimated the importance of DNA".
I like Carey's metaphor of DNA being like a script for a play. There is considerable room for variation and improvisation - that's the epigenetics. Genotype is the DNA, phenotype is the epigenetic expression.
Epigenetic modification come through methylation (turning genes off) and histones (which is a little more subtle)
blinki.st/c87019b62fd6?b…
Carey outlines the implications of the Dutch Hunger Winter. Birth weight was affected, depending on which stage of pregnancy the child was born in.
Carey outlines the implications of the Dutch Hunger Winter. Birth weight was affected, depending on which stage of pregnancy the child was born in.
If the starvation came in the later stages of pregnancy, the child's birth weight was lower. They stayed smaller and were less likely to become obese. If earlier, their birth weight was closer to normal...
Later in life though, those whose mothers starved in early pregnancy were more likely to become obese.
The theory is that environmental factors play a role in development, and epigenetics may be involved.
The theory is that environmental factors play a role in development, and epigenetics may be involved.
blinki.st/c87019b62fd6?b…
Sometimes we pass on epigenetic information. This runs contrary to evolutionary theory and DNA dogma. Returning to the Dutch Hunger Winter, the grandchild of a survivor is also more likely to be obese. But is this association rather than causation?
Sometimes we pass on epigenetic information. This runs contrary to evolutionary theory and DNA dogma. Returning to the Dutch Hunger Winter, the grandchild of a survivor is also more likely to be obese. But is this association rather than causation?
But there is other evidence of epigenetic inheritance. In Sweden, boys who experienced protracted hunger before puberty had sons who were less likely to die of cardiovascular disease. If well nourished, sons more likely to get diabetes.
Long bow to draw based on that info.
Long bow to draw based on that info.
Mice studies apparently support epigenetic transmission. This theory was first proposed by Lamarck. en.m.wikipedia.org/wiki/Jean-Bapt…
blinki.st/c87019b62fd6?b…
"Childhood trauma seems to have epigenetic effects." this fits with the adverse childhood experiences study findings, and it might have something to do with cortisol receptor expression (at least in mice).
"Childhood trauma seems to have epigenetic effects." this fits with the adverse childhood experiences study findings, and it might have something to do with cortisol receptor expression (at least in mice).
Here is a relatively recent paper about adverse childhood experiences. sciencedirect.com/science/articl…
I see it very frequently in patients who are referred to the pain clinic, and it's why taking a psychosocial history is so important.
I see it very frequently in patients who are referred to the pain clinic, and it's why taking a psychosocial history is so important.
An interesting set of blinks. @threadreaderapp unroll please.
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