Not the first, but a quite comprehensive analyses of Omicron neutralization resistance with @theodora_nyc, @NussenzweigL
Bottom line is fairly consistent with other mini-studies out this week, some quantitative discrepancies between groups
Bottom line is fairly consistent with other mini-studies out this week, some quantitative discrepancies between groups
By Fabian Schmidt, @FraukeMuecksch, Yiska Weisblum, Justin Da Silva, Eva Bednarski, Alice Cho @VinciZijun, @c_gaebler @marinacaskey
Link to full manuscript: drive.google.com/file/d/1zjJWsy…
Link to full manuscript: drive.google.com/file/d/1zjJWsy…
We compared Omicron to an antibody resistant spike (PMS20) that we previously designed. Omicron distribution of changes and neutralization properties are similar to PMS20. Suggests that antibody evolutionary pressure drove Omicron emergence 
Longitudinal analyses of plasma from convalescent individuals (1m, 6m, 12m after infection) shows substantial Omicron neutralization escape
Longitudinal analyses of plasma from individuals who were vaccinated only (2x mRNA or 1x J&J) shows substantial Omicron escape
KEY POINT: Increasing immunity with an mRNA booster shot on top of prior infection or prior 2x mRNA vaccination confers 30x to 200x higher neutralization titers vs Omicron or PMS20
It is time to discard the notion that two doses of mRNA means “fully vaccinated”
It is time to discard the notion that prior SARS-CoV-2 infection means you don’t need to be vaccinated.
It is time to discard the notion that prior SARS-CoV-2 infection means you don’t need to be vaccinated.
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