Paul Bieniasz Profile picture
Virologist: Science, Politics, Rants
🆔 Richard Nathan || Vaccinated 💉 🦠🐶🐕☕⚾😷🐾 Profile picture agvalex Profile picture 2 added to My Authors
Jan 14
A central, and perhaps the most avoided question is:

How many COVID deaths, (mostly of old people) is a price worth paying for a return to normality? Noting however, that those who return to normality will have answered on behalf of others, who will actually pay the price
Read 4 tweets
Dec 12, 2021
Not the first, but a quite comprehensive analyses of Omicron neutralization resistance with @theodora_nyc, @NussenzweigL
Bottom line is fairly consistent with other mini-studies out this week, some quantitative discrepancies between groups By Fabian Schmidt, @FraukeMuecksch, Yiska Weisblum, Justin Da Silva, Eva Bednarski, Alice Cho @VinciZijun, @c_gaebler @marinacaskey
Link to full manuscript: drive.google.com/file/d/1zjJWsy…
Read 8 tweets
Sep 20, 2021
Our paper on #polymutant SARS-CoV-2 spikes (led by Fabian Schmidt and Yiska Weisblum with @theodora_nyc and @NussenzweigL) now published in @Nature
nature.com/articles/s4158…
rdcu.be/cx5qM It shows that plasma antibodies target numerous epitopes in SARS-CoV-2 spike such that ~TWENTY mutations are needed for neutralization escape from polyclonal antibodies elicited by infection or vaccination.
Read 5 tweets
Jan 20, 2021
Our new preprint with @NussenzweigL @theodora_nyc and @bjorkmanlab

K417N, E484K and N501Y in SARS-CoV-2 “variants of concern” in UK, SA and Brazil are antibody escape mutations.
biorxiv.org/content/10.110… Each confers resistance to commonly elicited RBD neutralizing antibodies cloned from mRNA vaccinees
Together, K417N, E484K and N501Y confer some (not complete) resistance to neutralization by vaccine recipient polyclonal plasma.
Read 8 tweets