Eric Feigl-Ding Profile picture
Dec 13, 2021 10 tweets 6 min read Read on X
⚠️OMICRON “EVADES” NEUTRALIZATION—1st ever #Omicron variant study of blood from Moderna, Oxford-AstraZeneca, Pfizer vaccinated, vs survivors of Alpha, Beta, Delta variants. Omicron #B11529 evasive—but 2x Pfizer/mixed stronger>> convalescent; 3x hit best.🧵 medrxiv.org/content/10.110…
2) “We found that sera from vaccinated individuals neutralized the B.1.1.529 variant to a much lesser extent than any other variant analyzed. Neutralization capacity against #Omicron was maintained best against sera of “infected + 2x vaccinated” or “2x vaccinated + infected”
3) it’s clear vaccine neutralization of #Omicron is much harder than any other variants tested - Alpha, Beta, or Delta. Though 2 doses of Pfizer or Pfizer+AstraZeneca mixed vaccination had somewhat better performance against #Omicron. But 2x AstraZeneca not good enough.
4) I’m kind of surprised that 2x doses of Pfizer showed stronger benefit than 2x doses of Moderna. Moderna is a >3 times the dose. But the author says it might be due to interval difference. Will want to see more duration data.
5) I think it’s clear we need boosters. But also maybe variant-adapted newly #Omicron-tailored vaccines in the near future.
6) This above Innsbruck neutralization study matches the drop in vaccine effectiveness seen in the UK — where 2x shots of Oxford-AstraZeneca has little benefit without a booster, and 2 shots of Pfizer slightly better but still only in the low to mid 30% VE without a booster.
7) So how bad is the VE data for 2 AZ doses? Well let’s walk through it… the table tells more about the efficacy against #Omicron beyond the figures above. 2 shots of Oxford-AstraZeneca don’t even have enough data for those <25 weeks. But for 25+ weeks, the 5.9% VE stood out.
8) Another study found that those infected with the original strain much sharper drop off in ability to neutralize #Omicron. ➡️Bottomline: DO NOT RELY ON PAST INFECTION TO PROTECT YOU from Omicron! Get vaccinated / boosted!

And follow my former mentor: @AliNouriPhD
9) Semi-good/bad news with 2 shots of Pfizer, the VE starts at 88% between 2-9 weeks after the 2nd shot. Good, but it quickly drops to 48.5% by weeks 10-14. Then drops to 31% by 15-19 weeks. Then it hovers at 36.6% at 20-24 weeks. Then 34.2% at 25+ weeks. But 75.5% w/ booster!👀
10) By now, i hope everyone understands how much worse #Omicron is in evading vaccines and past infection immunity —by leaps and bounds worse by old strain and worse than Delta. We need some radical realism, not delusional dismissive ness that Omicron won’t hit hard. Booster now!

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More from @DrEricDing

Jun 12
⚠️SURGING COVID cases & hospitalizations in Madrid, Spain🇪🇸—hospitalizations for COVID has now exceeded also 2022-2023. This is the globally surging KP3 variant (US too)—it is highly evasive against past immunity—you’re not immune. Take preventive action.
comunidad.madrid/sites/default/…

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2) New York City’s COVID cases are also increasing, as noted by @emmagf. June is not normal cold and flu season at all. This shows that this KP3 surging despite non-flu season means it’s a troublemaker. Image
@emmagf 3) Hawaii’s ERs also have gotten slammed hard by an off-season COVID surge. This isn’t normal at all for June. This is why we need to be on alert. Image
Read 7 tweets
Jun 11
📍Breaking—MASK BAN PASSED AGAIN—North Carolina Republicans have again voted to pass a new ban on mask wearing. Only a weak partial medical exemption added for PUBLIC areas—but, on private properties, like at grocery stores or at a workplace, the bill now says people can still be “REQUIRED TO REMOVE MASKS” if demanded by employer or owner (your health be damned). But, thank goodness Halloween masks will still be allowed.
motherjones.com/politics/2024/…Image
2) “Many healthcare professionals have expressed concerns that their patients would not be able to stay safe against the spread of Covid-19 and other infectious diseases.” Image
3) the scary thing is that “The bill, which was drafted in response to people wearing masks at Pro-Palestinian protests, can be passed by the General Assembly **even if Democratic Governor Roy Cooper vetoes** it through an override.”
Read 8 tweets
Jun 11
⚠️Our future cancer risks of #COVID are emerging and likely real. SarsCOV2 induces several of the same carcinogenic cellular changes as other viruses known to cause cancers. Most cancers take 10-20 years to fully emerge (eg 🚬 or HPV-cervical), but some cancers may emerge sooner.
2) “We are completely under-investigating this virus,” said Douglas C. Wallace, a University of Pennsylvania geneticist. “The effects of repeatedly getting this throughout our lives is going to be much more significant than people are thinking.”
wapo.st/3Rox991
3) We know from studies that Long COVID disease burden is already on par with the burden of heart disease and cancer. Now imagine if LC further stacks additional risks to these other major disease burdens in the decades to come.
Read 5 tweets
Jun 10
Cool time lapse of a dozen rapid Covid tests—by @jeremyfaust over 11 days. Staggeringly high viral load = rapid bright test line. CDC would have said it’s okay to go out on day 2. What a load of crap, and every epidemiologist I know agrees. #COVIDisnotover
2) this is why I’ve been adamant that @CDCDirector Cohen has morally abdicated CDC’s duty to disease “control and prevention” with her horrible leadership. And yes she was on board with this—she was at the press conference for relaxing Covid rules.
3) here is the full story about how @CDCDirector Cohen has just about done the worst thing to torpedo @CDCgov’s normally stellar reputation. More than Walensky and more than Trump CDC director Redfield.
Read 4 tweets
Jun 9
📝PERSONAL NOTE—Sometimes I share info that might be unpopular to some. For example, stocking up on certain antiviral flu medications (which FDA does allow for prevention & stopping transmission even if you’re not sick—so much poor info/misinfo from a few ignorant MDs)… But many experts know in their hearts they would do for their own family secretly/quietly, but would tell others not to, or would keep what they do a SECRET. Examples:

📌During early pandemic—many MD’s stockpiled CASELOADS of expensive COVID tests for holiday parties—but told nobody outside their family/friend circles about the strategy.

📌Many doctors & their friends stocked up on Paxlovid or Flu medicines or Antibiotics BEFORE GOING ON VACATION because they knew it was a good idea, but ashamed to tell anyone they did it for themselves.

📌Many doctors wanted to wait for Novavax or got extra shot of Novavax or extra vaccine booster shot for themselves and their family above/beyond FDA/CDC recommendations, and then told nobody.

📌Many doctors obtain Plan B, plus countless other medications for their own family just in case.

📌Or bought all their friends at work HEPA FILTERS / upgrading the ventilation systems for all rooms, but all the while, turned around and told the public at same time that “COVID IS NOT AIRBORNE”—➡️oh wait that last one wasn’t a person, it was actually just Geneva HQ office of the WHO being hypocrites (yes, they did this!!)

💡But I am a no bullshit guy. I will tell the public the PRECAUTIONARY thing that many experts are thinking/doing even if is sometimes unpopular or if they are doing it quietly for their own family. Yet some people are mad at me for “talking about the Emperor’s New Clothes” and lifting the veil on the insider world of many doctors and experts doing for their own family. But some claim that I’m supposedly a bad person for sharing such info? I’m just a messenger—don’t shoot the PUBLIC HEALTH messenger please.

(SIDE NOTE #1—I didn’t go against any FDA/CDC rules since preventive prescribing and prophylactic use is allowed for flu antivirals)

(SIDE NOTE #2—I was personally invited by senior WHO officials to Geneva in 2021 when offices mostly closed except to senior/critical staff. I saw and was told stuff most people in the world have not seen/heard. So please don’t lecture me about what about rules being bent during the pandemic.)
2) For those wanting to know the context of the above… please read the FULL THREAD 🧵below why getting a few extra flu antiviral medications might be a good idea… again read the full thread for full context.
3) I also emphasized that there is no need to lie / you should not lie to your doctor. CDC/FDA does allow for prophylactic use. And this famous trial proved that Tamiflu for PREVENTION worked well for stopping transmission & preventing illnesses. But many MD’s ignorant of this.
Read 6 tweets
Jun 8
💡LISTEN UP—I would start STOCKPILING these flu medicines (xofluza, relenza, Tamiflu) for your family STARTING NOW. If bird flu is ever human-to-human transmissible… you will regret it when near-certain shortage hits. (Many epidemiologists/MD friends all agree & already started)

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2) Yes these are all prescription flu medicines. You need a prescription. I’m saying next time you get flu symptoms of any sort, ask for it. I’m just sharing what many epidemiology and medical colleagues are already doing. Don’t shoot the messenger.
3) I’m aware this pre-stockpiling of prescription medicines is an extremely privileged thing where not everyone can do it. And you should only take it if you have the flu, but it doesn’t hurt to ask your doctor if they can dispense it if they deem appropriate. Others agree.
Read 13 tweets

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