1/ Big weekend for those of us thinking about eliciting mucosal immunity for protection against SARS-CoV-2. New studies by @florian_krammer, @VirusesImmunity and @McMasterU herein as well as an update on our own work.
2/ First a new study posted by @florian_krammer on salivary Ab titres post 2x mRNA vaccinated, comparing with previously infected and subsequently vaccinated.
3/ Their mRNA vaccination data shows something very similar to what we see: modest sIgA titres in the saliva in <50% subjects. medrxiv.org/content/10.110…
4/ Next a new study published by @VirusesImmunity looking at the impact of intranasal priming on lung resident B cells. science.org/doi/10.1126/sc…
5/ And a new phase 1 trial out of McMaster testing aerosolized Adenovirus based COVID-19 vaccine as a boost theglobeandmail.com/canada/article…
6/ What is missing is that we don’t know if anti-SARS-CoV-2 IgA is truly associated with protection against breakthrough infection. That important piece is now in our study - an update on our Medrxiv is in the works. Will keep you posted!
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