The main reason for health benefits of fish oil, and the reason high doses are usually required to see benefit, is because fish oil counteracts the harms of seed oils.
Removing dietary seed oils would likely bring much greater benefit.
Most Americans (95%?) consume seed oils copiously, and don't even know they're doing it.
Much the same can be said about aspirin, which blocks the formation of inflammatory cytokines from arachidonic acid as its main mechanism. (Though aspirin has other mechanisms.)
Seed oil consumption leads to higher levels of AA.
Daily aspirin reduced deaths due to several common cancers - by a lot in many cases
"In terms of effect size, he said, “the closest thing we’ve seen in other research... is the studies that were done of orphans in Romania. The effects of institutionalisation and lack of interaction on them were profound, but what we’re seeing here is on par with that.”
Preliminary data shows "a significant depression in the number of words spoken to kids and, as you can imagine, a massive increase in TV exposure, and a decline in meaningful conversations. Time spent engaged with a caregiver is way down.”
The key contribution of platelet and vascular arachidonic acid metabolism to the pathophysiology of atherothrombosis
Linoleic acid (seed oils) -> arachidonic acid -> atherothrombosis, i.e. blood clotting and platelet activation leading to blocked arteries academic.oup.com/cardiovascres/…
Aberrant blood clotting appears to be highly related to Covid severity.
High PAI-1 precedes a first heart attack, indicating blood coagulation as a primary risk factor ahajournals.org/doi/10.1161/01…
PAI-1 is not only elevated in the elderly but also significantly induced in a variety of pathologies associated with the process of aging academic.oup.com/cardiovascres/…
A null mutation in the gene that encodes PAI-1 is associated with *7 years* longer lifespan. This is in an Amish community. They also have no diabetes. science.org/doi/10.1126/sc…
Concentrations of lead (the metal) in blood are a risk factor for heart disease and death on a par with, or greater than, smoking.
How often do you hear that? If you have CAD, does your doc check your blood lead level, or just prescribe a statin?
"Our findings suggest that, of 2·3 million deaths every year in the USA, about 400,000 are attributable to lead exposure, an estimate that is about ten times larger than the current one."
Men in the top third of bone lead level - which by definition one third of men are - had *8x* the risk of death from heart disease. pubmed.ncbi.nlm.nih.gov/19738141/