The main reason for health benefits of fish oil, and the reason high doses are usually required to see benefit, is because fish oil counteracts the harms of seed oils.
Removing dietary seed oils would likely bring much greater benefit.
Most Americans (95%?) consume seed oils copiously, and don't even know they're doing it.
Much the same can be said about aspirin, which blocks the formation of inflammatory cytokines from arachidonic acid as its main mechanism. (Though aspirin has other mechanisms.)
Seed oil consumption leads to higher levels of AA.
"In terms of effect size, he said, โthe closest thing weโve seen in other research... is the studies that were done of orphans in Romania. The effects of institutionalisation and lack of interaction on them were profound, but what weโre seeing here is on par with that.โ
Preliminary data shows "a significant depression in the number of words spoken to kids and, as you can imagine, a massive increase in TV exposure, and a decline in meaningful conversations. Time spent engaged with a caregiver is way down.โ
The key contribution of platelet and vascular arachidonic acid metabolism to the pathophysiology of atherothrombosis
Linoleic acid (seed oils) -> arachidonic acid -> atherothrombosis, i.e. blood clotting and platelet activation leading to blocked arteries academic.oup.com/cardiovascres/โฆ
Aberrant blood clotting appears to be highly related to Covid severity.