Someone recently asked for a thread on the evidence of higher AE for vaccination of Covid survivors v naive recipients. EVERY study I am aware of so far is consistent with this finding. Please update or correct the list that follows.
Efrati nature.com/articles/s4159… "Short-term severe symptoms that required medical attention were found in 6.8% among the post-infected individuals, while none were found in the infection naïve population."
Menni ncbi.nlm.nih.gov/labs/pmc/artic… "Systemic side-effects were more common (1·6 times after the first dose of ChAdOx1 nCoV-19 and 2·9 times after the first dose of BNT162b2) among individuals with previous SARS-CoV-2 infection than among those without known past infection."
Mathioudakis ncbi.nlm.nih.gov/labs/pmc/artic… "A prior COVID-19 infection was associated with an increased risk of any side effect.... It was also associated with an increased risk of severe side effects leading to hospital care."
Krammer "Vaccine recipients with preexisting immunity had systemic side effects at higher frequencies than those without preexisting immunity" nejm.org/doi/full/10.10…
Raw ncbi.nlm.nih.gov/labs/pmc/artic… "The proportion of participants reporting at least one moderate-to-severe symptom was higher in the previous COVID-19 group"
Tre-hardy "Common side effects such as articular pain, muscular pain, headache, fatigue, fever, adenopathy and oedema from the first dose appear to be more frequent and severe in previously infected individuals" ncbi.nlm.nih.gov/labs/pmc/artic…
Here's a list of all the studies I've identified that find NO elevated risk of AE for vax of Covid survivors.
Takeaway: Shenai, et al find trivial, temporary reduction in risk of any infection (usually mild) from vax of previously infected (NNT=218). In exchange, Covid survivors get highly elevated risk of AE, including serious (including hospitalization and ER). ncbi.nlm.nih.gov/labs/pmc/artic…

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More from @ToddZywicki

17 Dec
Just to clarify my interest for my new followers (thank you!). I am concerned about vaccinate mandates, especially for those with natural immunity (like me). So my focus is on (1) whether policymakers should recognize NI as part of any mandates and (2) whether mandates are legal.
I don't generally comment on the efficacy of vaccines in preventing serious illness and death. I don't comment on any specific risks of vaccines or non-vaccination (myocarditis, etc.) except as they relate to compelled vaccination. Those are not directly relevant to mandates.
I don't comment on the efficacy of particular therapeutic treatments (repurposed drugs, etc.). Those are questions that you should decide with your doctor. That is my WHOLE POINT--everyone has different circumstances and medical histories. One-size-fits-all medicine is barbaric.
Read 9 tweets
17 Dec
David Leonhardt, "Omicron Threatens Red American: In many communities mot adults remain unvaccinated." He says, "Omicron seems to be qualitatively more contagious than any earlier variant." Omicron must be spreading faster in low-vax states? nytimes.com/2021/12/17/bri…
I'll use the list on Becker's Hospital Review. The 5 least-vaxxed states (from 51-46): Idaho, Wyoming, Alabama, Mississippi, Louisiana (note a combination of warm and cold weather states). 5 most-vaxxed (from 1-5). beckershospitalreview.com/public-health/…
Idaho Image
Read 13 tweets
10 Dec
Most readers here recognize that one of the major reasons for the superiority of NI>vax is the presence of IgA antibodies. Good illustration here of the inferior level of IgA abs production provided by vaccines and rapid decay. journals.plos.org/plosone/articl…
For non-technical readers, basic idea is IgA antibodies are produced by in the nose and respiratory passages and are the first line of defense against respiratory viruses. Current gen vax is intramuscular injection and as Figure 2 shows here, produces minimal IgA protection.
This is why vaxxed get infected. But more than that, vaxxed can get infected and carry virus in their nose and mouth for days before immune system activates. So vaxxed (1) produce same viral load as unimmune, unvaxxed and (2) can superspread without knowing it for days.
Read 11 tweets
8 Dec
Another early and important paper on NI, vax, and boosters from the canary in the coal mine (Israel). Some novel and original data here on so-called "hybrid immunity" (the first I've seen at least). medrxiv.org/content/10.110…
Baseline finding reaffirms yet again uncontestable conclusion: NI provides superior and far more durable protection against infection than vaccination. Protection of NI at 8-10 months is equivalent to vax at 0-2 months and protection of NI at 12+months to vax at ~3 months.
Figure 3C is booster data. Authors definition of "Booster" is interesting: "Booster: Individuals who received a third (booster) dose 12 or more days previously and had not been infected before the start of the study period." Why 12 days?
Read 12 tweets
7 Dec
pubs.acs.org/doi/10.1021/ac… "By tracking the evolutionary trajectories of vax-resistant mutations in more than 2.2 million SARS-CoV-2 genomes, we reveal that the occurrence and frequency of vaccine-resistant mutations correlate strongly with the vax rates in Europe and America."
"Moreover, from Figure 4, one can see that the frequency of the Y449S mutation has a tendency to increase similar to that of the fully vaccinated ratio...
Read 8 tweets
6 Dec
Apparently now they are going to change the definition of "leaky vaccine" along with "herd immunity" and "vaccine" to that it "reduces" infection and transmission instead of "prevents" it?
healthline.com/health-news/le… "“These vaccines also allow the virulent virus to continue evolving precisely because they allow the vaccinated individuals, and therefore themselves, to survive,” said Venugopal Nair, who led the research team...
"These less-than-perfect vaccines create a “leaky” barrier against the virus. Vaccinated individuals may get sick but have less severe symptoms, but the virus survives long enough to transmit to others, which allows it to survive and spread throughout a population....
Read 4 tweets

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