I recommend this thread on the Lieber case and conviction - several interesting details. My own thoughts are in the next few tweets (1/10)
You can come at this story from several directions. One is the position of US universities as a destination for hard-working and talented people from around the world. This is a huge benefit for the country, and if we mess that up we are idiots. (2/10)
But (a 2nd angle) China is in its own category (size, economy, and more). The Chinese government aggressively seeks out economic and technological advantage, and they definitely use (or try to use) students and post-docs for this. (3/10)
Well, nation-states do this sort of thing. But that doesn’t mean that the US should ignore it or make it easier. China doesn’t make it easy to learn what they’re doing, but the far more open US system is an attraction that comes with its own difficulties. (4/10)
Now, the government pursued no harder-to-prove espionage charges in the Lieber case. They frankly didn’t have to bother, because Prof. Lieber made it very easy for the prosecution to turn him into an example anyway. (5/10)
That’s the third angle on this story. Through some combination of carelessness, cluelessness, and hubris, Lieber violated the law, lied about that, and then admitted both of these to the FBI on video. There’s no getting around any of that. (6/10)
But the laws he violated are about finance and disclosure. It is not illegal to take money from to be part of the Chinese “Thousand Talents” program, but it is illegal to conceal that from US government granting agencies, and to bring in undeclared packages of cash. (7/10)
The US government got everything they wanted out of this case in the easiest way possible. That’s why they made such a big deal out of the arrest and prosecution. It was a perfect opportunity. (8/10)
It’s hard for me to make this into a big stand for academic freedom when this case involves such foolish, blatant wrongdoing. Other “Thousand Talents” cases might well cross into that territory, but this might make that less likely to happen. The message has been sent. (9/10)
The openness of our academic research system, the good that it does us, the opportunities it presents for a government like China’s, and our own desire to protect some national assets without ruining other ones are still in conflict. How can they not be?(10/10)

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More from @Dereklowe

23 Dec
I appreciate Eric saying this after some of us sort of jumped on him about this issue last night! Paxlovid is a good example of where small-molecule synthesis falls on on the difficulty scale when compared to things like mRNA vaccines - here's a thread (1/13)
The mRNA vaccines are intrinsically hard to manufacture - RNA biotechnology on scale is practiced in only a few countries around the world, and the nanoparticle formulation is particularly challenging to scale up and to get right. (2/13)
Small-molecule synthesis (though no picnic) is easier than that - there are generic drug manufacturing facilities in many more countries, and many of these can potentially adapt to processes like the Paxlovid synthesis. That's the good part. (3/13)
Read 13 tweets
26 Jun
Since I keep getting inquiries about the idea of antibody-dependent enhancement (ADE) problems with the coronavirus vaccines, here are some fresh data (1/5)
In May, the US had 18,000 deaths from Covid-19 infections. First: if the vaccines weren’t working, you’d expect these deaths to show roughly the same proportion as that of vaccinated and unvaccinated people in general. (2/5)
And if we had a real ADE problem, you could expect proportionally *more* deaths among the vaccinated, because ADE makes subsequent infections worse - the “enhancement” part. (3/5)
Read 5 tweets
5 May
@christymaginn (1/x) There are several bottlenecks to vaccine production, all jostling for the #1 position. One is equipment. Mixers for the mRNA lipid nanoparticles, e.g. Some types of filtration material (not patented!) are in very short supply as well, and there are others.
@christymaginn (2/x) Another bottleneck is in key materials like the lipids needed for the mRNA vaccines. Supply of these has been ramping up, but there's still only so much of these things in the world, and their synthesis is labor-intensive.
@christymaginn (3/x) A really tough one is expertise. All of these processes (mRNA, adenovirus) need hands-on tech transfer to troubleshoot as they ramp up, otherwise production can be spotty with poor QC pass rates. There simply aren't enough experienced people to go around!
Read 5 tweets
31 Dec 20
(1/8) The UK authorities are now trying to spread out the two doses of the Pfizer/BioNTech vaccine as well, in order to get more people the first shot now. A similar situation to what I wrote about yesterday: blogs.sciencemag.org/pipeline/archi…
I see why they’re proposing this, of course. The UK is in bad shape, with the new coronavirus variant spreading quickly. And we have evidence that the first shot really does seem to be immunogenic. BUT. . . (2/8)
. . . There are important things we don’t know. How long does immunity last if you’ve only had one shot? How well does the second booster shot work if the gap between them is longer? (3/8)
Read 8 tweets
16 Nov 20
Absolutely wonderful news from Moderna: 94% vaccine efficacy, zero severe coronavirus cases, no severe adverse events, and one-month stability under standard refrigeration.

We’re winning. Hang on, hang on, hang on and stay safe. We’re going to win.
Thoughts on the Moderna results this morning - safety, efficacy, and more. The vaccine news is very good, especially when it's illuminated against grim pandemic news in general: blogs.sciencemag.org/pipeline/archi…
Read 4 tweets
7 May 20
You may have seen claims from people promoting hydroxychloroquine that there are numbers from Italy that prove that it's a prophylactic treatment against COVID-19. These numbers are complete fiction. (1/5
There are at least two mentions in media sources (one from an Italian newspaper, one from an interview in the Israeli press) about the Italian Rheumatology Society monitoring their patients who are taking HCQ for coronavirus cases. (2/5)
These sources say that 65,000 such Italian patients have been monitored and that only 20 of them have been diagnosed positive. *This is false*. I dug into the numbers here, and they did not add up (3/5):
blogs.sciencemag.org/pipeline/archi…
Read 5 tweets

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