Encouraging news out of South Africa. Study data has suggested South Africa’s Omicron peak has indeed passed with NO major spike in deaths OR hospitalizations.
The study looked at the rate at which the fourth surge in cases progressed in the South African city of Tshwane, which researchers described as the "global epicentre" of the Omicron wave.
Researchers looked at hospital records from a Tshwane hospital system and compared them to prior surges. Based on their analysis, the omicron wave "spread and declined in the City of Tshwane with unprecedented speed peaking within 4 weeks of its commencement."
The study determined that the wave peaked during the week of Dec. 5th, roughly four weeks after an exponential increase in cases was observed. According to the researchers, peak hospital bed occupancy during the omicron wave was half of what was observed during the Delta wave,
and the distribution of patient ages was younger. Omicron currently accounts for 95% of sequenced cases in the Gauteng Province, where Tshwane is situated.
"The changing clinical presentation of SARS-CoV-2 infection is likely due to high levels of prior infection and vaccination coverage," researchers wrote, adding that roughly two thirds of Tshwane residents have some form of immunity from COVID-19, either from vaccination or
prior infection.” You can read the study here: sciencedirect.com/science/articl… and for more reading: nytimes.com/2021/12/30/wor…

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More from @sailorrooscout

2 Jan
“Breakthrough” infections DO NOT mean vaccines don’t work. Remember, they are preventives, NOT cures. One can still contract COVID once vaccinated. As long as that vaccine is preventing you from facing severe disease and worse, it IS working and doing what it was designed to do.
The term infection refers to the virus entering and being detectable in your system regardless of whether OR NOT it makes you sick, whereas the term illness refers to the virus entering, being detectable in your system AND making you sick. It it important not to conflate the two.
The first thing to know about the COVID-19 vaccines is that they’re doing exactly what they were designed and authorized to do. Since the vaccines first started their rollout late last year, rates of COVID-19 disease have taken an unprecedented plunge among the immunized.
Read 12 tweets
30 Dec 21
Them: Is there any other vaccine in history that required three doses in a year and yet still didn’t prevent transmission of the virus it was meant to protect against?

Me: Your childhood vaccinations would like a word with you.
Before I forget, reminder that your TDap: Tetanus-Diphtheria-Pertussis (every 10 years) are technically a repetitive vaccine series or rather boosters during adulthood. HPV is another vaccine that could fit here as well.
“Even the measles vaccine, which is incredibly effective, fails to protect about 3% of vaccinated individuals who are exposed to the virus. Jonas Salk's polio vaccine-hailed a medical miracle- was 80% to 90% effective at preventing paralysis caused by the polio virus.”
Read 4 tweets
30 Dec 21
Immunity is more than just neutralizing antibodies.

Why? Because MOST of your T-cell responses from vaccination or previous infection STILL recognize Omicron.

Let’s talk about that!🧵
Immunological memory consists of antibodies, memory B-cells, memory CD8+ T-cells, and memory CD4+ T-cells. These responses are what give us enduring protection even against newly emerging SARS-CoV-2 variants.
Immunological memory is probably the most important feature of immunity as it allows us to better respond when the threat is encountered a second time. Against SARS-CoV-2, it helps to determine protection against reinfection, disease risk, and vaccine efficacy.
Read 14 tweets
28 Dec 21
A new study shows Omicron infection ENHANCES neutralizing immunity against Delta, ESPECIALLY in those who are vaccinated, suggesting that Omicron will help push Delta out, as it should DECREASE likelihood that someone infected with Omicron will get re-infected with Delta. 🧵
Researchers enrolled both previously vaccinated and unvaccinated individuals who were infected with SARS-CoV-2 in the Omicron infection wave in South Africa soon after symptom onset. They then measured their ability to neutralize both Omicron and Delta virus at enrollment versus
Read 8 tweets
27 Dec 21
Rates of COVID-19 Cases and Deaths by Vaccination Status per the CDC:

Unvaccinated: 451 cases per 100k
Vaccinated: 134 cases per 100k
Boosted: 48 cases per 100k

Unvaccinated: 6.1 deaths per 100k
Vaccinated: 0.5 deaths per 100k
Boosted: 0.1 deaths per 100k
Source for information above can be found here:
covid.cdc.gov/covid-data-tra…
Data posted on December 17th
Summary:
•People who were unvaccinated had a greater risk of testing positive for COVID-19 and a greater risk of dying from COVID-19 than people who were fully vaccinated
•Unvaccinated people in all age groups had higher case and death rates than fully vaccinated people
Read 5 tweets
26 Dec 21
Good morning! I hope everyone had a wonderful holiday yesterday. ☃️🎁🎄

Currently working on a thread that’s shows while Omicron is more transmissible than Delta, it is LESS fusogenic and LESS pathogenic than both Delta AND ancestral SARS-CoV-2 if it is of any interest.
A study out of the University of Tokyo shows while Omicron is more transmissible than Delta, it is LESS fusogenic and LESS pathogenic than both Delta and ancestral SARS-CoV-2. In addition, Omicron infection in the lung is significantly LOWER.

Let’s talk about that and more!🧵
Source for the information above can be found here:
drive.google.com/file/d/1rhCazF…
nature.com/articles/s4158…
For definitions and some general background reading I recommend:
pubmed.ncbi.nlm.nih.gov/33348900/
Read 12 tweets

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