Thread by @sanamloghavi

The story of 1 day in the life of a #hematopathologist… I’m too exhausted to make a fancy educational thread but here are some amazing 🔬 pics for your viewing pleasure. I diagnosed all cases in one day 🤯 only at @MDAndersonNews Happy almost weekend people 🥂 #hemepath 🧵 1/n

Myeloproliferative neoplasm w/ concurrent BCR::ABL1 and JAK2 V617F ..the megekaryocyte morphology is clue to something beyond CML #mpnsm #PathOutPic 2/

BPDCN with perfect so-called “hand mirror” (red) and “pearl necklace” (black) morphology #BPDCN #PathOutPic 3/

Chronic myeloid leukemia, BCR::ABL1 positive. Note PB left-shifted neutrophils, basophilia, BM micro megs and left-shifted myeloid hyperplasia with increased eosinophils in BM #hemepath #PathOutPic 4/

Post-essential thrombocythemia myelofibrosis in accelerated phase #mpnsm #hemepath #PathOutPic wild platelet clumps and tear drop cells!!! 5/

MDS with excess blasts and ring sideroblasts (basophilic stippling is a clue). Your hint for TP53 mut, hope you saw this awesome paper in @LeukemiaJnl by our @MDAndersonNews colleagues and our own @kanagalshamanna pubmed.ncbi.nlm.nih.gov/34975158/ #hemepath #mdssm #pathoutpic 6/

BCR::ABL1 pos B- lymphoblastic lymphoma with prominent necrosis. Cellular degeneration makes it hard to recognize blasts. Teaching point: Think B-ALL or monoblastic leukemia when you see prominent marrow necrosis #hemepath #pathoutpic FISH pic is BCR::ABL1 7/

Blast- phase of polycythemia Vera (AML) #mpnsm #hemepath #pathoutpic 8/

Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrbocytosis with JAK2 V617F and SF3B1 mut. Note meg morphology, erythroid dysplasia and platelet clumps. #hemepath #pathoutpic #mdssm #mpnsm 9/

And the grand finale.. because it’s not Friday if you don’t see a good acute promyelocytic leukemia with PML::RARA… note Auer rods.. #leusm #hemepath #pathoutpic 10/

And this right here is why I love my job.. the WHO index in its entirety (ok… I’m exaggerating …I know 😅 ) in one day….. #hemepath