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9 Jan, 6 tweets, 4 min read
Please do not make #Deltacron a thing. It's not a thing. Some of you should know better.

Summary: Cyprus uploaded 24 genomes to GISAID on Jan 7 that appear to be Delta-Omicron recombinants. This is likely contamination from single sequencing run.

Some tweet sources below:
Tom was right on top of this at the start. There seems to be a biased PCR amplicon from the ARTIC primer set that put a particular fragment of Omicron in with Delta fragments. #Deltacron
As @PeacockFlu mentioned, below details how the Delta sequences are NOT MONOPHYLETIC. Same Omicron fragment in multiple different Delta backbones. So you have to believe this #Deltacron recomb happened dozens of times just Cypus, just last few days. Nope.
As usual, @sailorrooscout gives the nice clean narrative summary of why #Deltacron isn't a thing.

We have real issues with Omicron and Delta - focus on those.
Updated thread from Tom with more technical explanation of how this can happen:

The researcher who uploaded the Cyprus sequences has responded to criticism via an email statement to a reporter (who does not quote anyone else). I've read statements several times, but am more confused. It does not address technical issues raised.
bloomberg.com/news/articles/…

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More from @BrianRWasik

Brian Wasik Profile picture
1 Jan
My 365 Best Films, 2022

Did this 5 years ago on FB. Updating. The best 365 films I've ever seen (no order). Based on my ratings (4.5 or 5 stars) on @letterboxd. I post one a day in a thread with an image.

I'm at: boxd.it/781V
001 01-January

PARASITE (2019)
Director: Bong Joon-ho
Cinematography: Hong Kyung-pyo Image
002 02-January

CROUCHING TIGER, HIDDEN DRAGON (2000)
Director: Ang Lee
Cinematography: Peter Pau Image
Read 4 tweets
Brian Wasik Profile picture
26 Sep 20
Is everyone just trying to piss me off?
To be clear, because I've collapsed into exasperation tweets:

This headline is not just incorrect, but false and misleading. #SARSCoV2 D614G has been a present lineage in Europe and NAmerica since the beginning of the pandemic. G has become more dominant than D. /1
We are not certain why G overtook D. Serendipity founder effects. Marginal increase in infectiousness. Some combination. With so many susceptible hosts, it seems unlikely there was any sufficient selection for G to 'outcompete' D. /2
Read 6 tweets
Brian Wasik Profile picture
10 Sep 20
I keep being left with the weight of this brilliant @edyong209 piece. It's about this pandemic, but it really correctly pokes at the raw nerve that is the American experiment at this moment.
theatlantic.com/health/archive…
We've arrived at some impasse. By a series of disasters and failures, the future of American hegemony is unclear to a majority of Americans. It's a point that Americans have not really collectively grappled with since before WWII. Some have with good reason, but not nearly all.
Yet instead of seeing the blank canvas as an opportunity to forge a new path, to resolve our character toward a hopeful future... we've retreated into resignation, cynicism.

Further saddled with leaders who indulge our self-loathing and self-pity.
Read 4 tweets
Brian Wasik Profile picture
18 Aug 20
I don't bemoan college students for anything. They were handed a deal from the bottom of the deck in many ways.

They have seen for the last 6 months that there are no 'adults' in leadership, no consequences or accountability. There is no strong and consistent modeling. /1
I'm sure the majority of college students do their best to take part in good practices, while a minority of transgressions get all the oxygen. In that way, their demographic is no different than any other over this pandemic. /2
The scolding of students for failing to adhere to University 'pandemic guidelines' is just another classic case of focusing on individual actions when structural forces drive events. /3
Read 4 tweets
Brian Wasik Profile picture
28 Jul 20
Today at @bakercornell we received sad news that Prof LeLand 'Skip' Carmichael passed away last night in Ithaca.

Skip was cherished family of Baker Institute and @cornellvet.

Instrumental in identification of epizootic Canine Parvovirus, development of the vaccine.
#virology
In ~1976 a severe haemorrhagic enteritis broke out in dogs and quickly spread worldwide. Skip and his team were key in identifying the parvovirus, and recognizing its likely homology to feline panleukopenia virus.

pubmed.ncbi.nlm.nih.gov/516347/
That homology was the basis for a rapidly developed vaccine based on FPV... which was improved to an attenuated formula developed at Baker by 1981. That has been the basis for all CPV vaccine formulations since.

pubmed.ncbi.nlm.nih.gov/6299142/
Read 4 tweets
Brian Wasik Profile picture
11 Jul 20
Gonna start @criterionchannl WESTERN NOIR series. First up: BLOOD ON THE MOON (1948) with Robert Mitchum. Dir: Robeet Wise.
The cinematography of Musuraca in BLOOD ON THE MOON is soooooo dark. Really amazing work. And looks so good on Mitchum, where Musuraca also lit him in the amazing Noir, OUT OF THE PAST.
Mitchum was the personification of conflict and a burden of personal demons. He needs to say so little. He acts with the look of his face, the way he carries his shoulders, the simple movements of his body.
Read 23 tweets

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