New study from Vietnam confirms Peter Aaby's observations on measles:
Compared with unvaccinated uninfected children, measles infected children had higher risk of hospitalisation in the first month, but thereafter their risk was substantially lower. bmcinfectdis.biomedcentral.com/articles/10.11…
Measles infection seems to train the immune system so it becomes better at defending itself against other unrelated disease organisms in the future.
But of course, this training comes with the risk of becoming severely ill from the infection itself. academic.oup.com/aje/article/14…
A safer way to obtain the immune training is measles vaccine, a live attenuated vaccine, which basically can be seen as a controlled way of getting a mild measles infection. Measles vaccine is also associated with lower risk of other infections. #NSEvac jamanetwork.com/journals/jama/…
Add-on: only in preprint, but in a randomised trial, measles-containing vaccine was associated with a 48% (17-67%) risk reduction in symptomatic COVID-19 and a 76% (12-94%) risk reduction in COVID-19 treatment. More trials underway: medicine.wustl.edu/news/global-tr… medrxiv.org/content/10.110…

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More from @StabellBenn

15 Jul 21
Skal Corona være en vaccinesygdom eller en børnesygdom?
Jeg afbrød min sommerferie for at give mit bud i @Orientering (efter 1 t 06 min). 1/n dr.dk/radio/p1/orien…
Lige nu er valget taget politisk: Corona er udset til at være en vaccinesygdom. Men der er et alternativ, der på en gang ville kunne sikre mere stabil pandemikontrol og spare ressourcer, der kunne bruges på at bedre folkesundheden. Det er at gøre Corona til en børnesygdom. 2/n
Hvordan tæmmer vi Corona til en børnesygdom? Ved at lade være med at fokusere på antal smittede og i stedet fokusere på hospitaliseringer. Lade være med at teste asymptomatiske, fjerne restriktioner og stoppe nedlukninger, og ikke mindst: lade være med at vaccinere børn. 3/n
Read 10 tweets
9 Jun 21
I support US colleagues in the request to FDA to refrain from fully approving any covid-19 vaccine, until the evidence base is mature enough to judge whether clinical benefits outweigh the risks in all populations. blogs.bmj.com/bmj/2021/06/08…
"Our petition doesn’t argue that risks outweigh benefits—or that benefits outweigh risks. Rather, we focus on methods and processes, outlining the many remaining unknowns about safety and effectiveness—and suggest the kinds of studies needed to address the open questions".
"regarding the elephant in the room: publicly raising any element of hesitation about covid-19 vaccines will be seen by some as irresponsible, stoking unfounded fears in the public’s mind and contributing to the “vaccine hesitancy” problem trumpeted every day....
Read 4 tweets
11 May 21
Back in Denmark after >6 weeks in Africa. Time was spent on two trials close to my heart. Here a brief introduction. First, the @EDCTP funded randomised trial of BCG vaccine to health care workers, as a potential bolster against COVID and other infections. edctp.org/projects-2/edc…
It is a two-center trial at #BandimHealthProject in Guinea-Bissau and at @Manhica_CISM in Mozambique. In March, we from Bandim visited the Manhica team, led by Dr. Pedro Aide and Lidia Nhamussua, to align study procedures before the launch of the trial in Mozambique. Great days with the Manica team - Dr. Pedro Aide on my left,
In Guinea-Bissau, we have enrolled ~300 health care workers. Our analyses show that >20% have COVID-19 antibodies; most have not noticed that they were ill. Perhaps this is why many Guineans said no to the COVID-vaccines that were rolled out in April. medrxiv.org/content/10.110…
Read 6 tweets
9 Apr 21
NEW PAPER OUT. We investigated the effect of rabies vaccine on the mortality of Danish pigs. Why did we do that - Danish pigs do not get rabies?
Here follows an explanation and the results of the study. #NSEvac sciencedirect.com/science/articl…
Our group has found that many child vaccines have important non-specific effects #NSEvac, affecting the risk of other infections. Live vaccines have beneficial #NSEvac. Non-live vaccines, in contrast, have been observed to have harmful #NSEvac in females. thelancet.com/journals/lanin…
In 2016, analysing data from a trial of a new non-live malaria vaccine (RTS,S), we found that girls had 2-fold higher all-cause mortality if they received RTS,S vs. a control vaccine. The RTS,S group also had more cerebral malaria and meningitis. mbio.asm.org/content/7/2/e0…
Read 9 tweets
20 Mar 21
The statements put forward by @GVDBossche have created anxiety. @GVDBossche has invited to discussion, but few scientists seem to have replied. The lack of response seems to generate more anxiety. I have received many requests to give my take and felt obliged to do so. 1/n
First a few words on my background: I am an MD working in epidemiology/global health>27 years. Our studies show non-specific effects of vaccines on other infections #NSEvac; I therefore also did immunological vaccine studies to understand mechanisms. 2/n thelancet.com/journals/lanin…
My main interest in COVID-19 vaccines is whether these new vaccines also have #NSEvac (So far none of them have been studied for their effect on other infections). Thus, vaccine immunology is not my main area, but I do know more than most. Hence my feeling of obligation. 3/n
Read 16 tweets
13 Mar 21
Det mener jeg også. Studiet antager, at en person, der tester positiv så lidt som een dag efter indexcase, er smittet af indexcase. Det kan skabe falsk association ml. høj CT og smitterisiko, hvis mange bare er familie ”lilla periode” - se figur.
Jeg har spurgt forfatterne, om de vil prøve med større vindue; formodningen er, at associationen mindskes. En anden måde test er ved at se på, hvor mange sekundærcases, der kom på hospital; formodningen er, at der var meget få blandt "sekundærcases" til de med højt CT.
Studiet bekræfter fund fra England og Spanien: der er flot korrelation mellem CT-værdi og smitterisiko. Det er det eneste studie, der angiver at finde smitte ved høje CT. Det kalder på grundig undersøgelse af om der kunne være fejlkilder a la ovenstående.
Read 4 tweets

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