This is insane. I have two co-firsts in JCI and JCI insight on T-cell differentiation out of the surgery branch of the NCI, a famous place for immunology who paid for my PhD and funded me as a pre-doctoral fellow
Why are famous journalists and anonymous virologists saying this??
They constantly attack me like this. Is it because my firsts are co-firsts? I was a team player and quite gracious and not avaricious with publications. I did not fight for glory so the postdocs I worked with got first position.
My contributions included finding the mechanism of T cell differentiation and how it was paracrine Via Fas and Akt.
What should I do about these people attacking me all the time?
Supervisors and trainees be aware- despite everything, supposedly like cofirsts being similar to firsts, people will still slander and defame and perhaps it is not really that way at all.
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In order for propaganda megaphones that cite Gupta on continuous reinfection being 'herd immunity' to sell the idea to the public they must first convince you all that reinfections will be more mild.
It's not the case. It depends on your immune system and other factors.
We are entering total information control. We have sources on the right claiming this is a safe route to endemicity and sources on the left like Zeynep that call me a crank for warning about severe reinfections, t cell harm, and t cell mediated harm.
These narratives coalesce and appear as a consensus to the public. A struggle ensues between authorities that want to power through endemicity versus those that want to mitigate a multi-pandemic of a diversifying set of viruses which emerged from wuhan 1.0
So I am looking at the T cell changes in long covid in comparison to other infections
The CD8 naive T cell changes in covid are similar to what happens with naive CD8 T cells in nasty infections
Acute sars cov2 is indeed different, but Long Covid changes have me concerned
I agree, there is a persistent activation that is driving differentiaion in Long Covid nature.com/articles/s4159…
This is similar to other infections but is NOT the same for a very important reason...
The reason being there is no integration of the virus into DNA. sars cov 2 is not a retrovirus. Our therapies and vaccines should have good efficacy. There is also no direct replication in the T cells, but could be an immune reservoir. biorxiv.org/content/10.110…
There are sars cov 2 naive persons, and infection will bring an end to the pandemic sooner
Infection-based immunity has brought us closer to ending the pandemic by virtue of immunity
Infection-based immunity has prolonged the pandemic and borne new iterations of sars cov 2 that can reinfect and cause severe disease, despite T-cell memory
Guys, whenever you bring up that I have said T cells contribute to harm and people say I am a T cell contrarian, show them this paper, "T Cells: Warriors of SARS-CoV-2 Infection."
This paper came out months after my preprint osf.io/2egsm/ but 2 weeks before my paper doi.org/10.3389/fimmu.… where I claimed T cell memory was contributing to harm in covid
It's cited 33 times and mine only 2
Balloux has made me self conscious about my H index lol
It's got such a feel-good title, "T cells- Warriors of sars cov 2 infection" Monica Gandhi even cited it by name about T cells in cov 2 infection
She must not have read it, lol, because it says the same thing I did, that memory t cells were harming pubmed.ncbi.nlm.nih.gov/33277181/
Next time I will be smart about making my write-ups more optimistic and accessible. It's got great paragraph headers.