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Anthony J Leonardi, PhD, MS Profile picture
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Jan 24 • 4 tweets • 2 min read
Damn, Zeynep is absolutely brutal

I'm not the only one who has said overshooting T cell responses have contributed to harm and not controlled cov 2 infection

Read these papers before you say I am the only one with this idea (I published it earlier)

This is so insanely disrespectful and unbecoming.

Have T cells stopped severe infections or has t cell memory stopped the pandemic

No!

Stop overselling T cell memory!!

All your BS has harmed T cells by overselling infection based immunity!
helsinki.fi/en/news/health… Here is a seminar where the likelihood of T cell mediated harm is discussed in Covid-19

This is becoming clear now!
Here is the link www2.helsinki.fi/en/unitube/vid…

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More from @fitterhappierAJ

Anthony J Leonardi, PhD, MS Profile picture
Jan 25
In order for propaganda megaphones that cite Gupta on continuous reinfection being 'herd immunity' to sell the idea to the public they must first convince you all that reinfections will be more mild.

It's not the case. It depends on your immune system and other factors. Image
We are entering total information control. We have sources on the right claiming this is a safe route to endemicity and sources on the left like Zeynep that call me a crank for warning about severe reinfections, t cell harm, and t cell mediated harm.
These narratives coalesce and appear as a consensus to the public. A struggle ensues between authorities that want to power through endemicity versus those that want to mitigate a multi-pandemic of a diversifying set of viruses which emerged from wuhan 1.0
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
Jan 24
This is insane. I have two co-firsts in JCI and JCI insight on T-cell differentiation out of the surgery branch of the NCI, a famous place for immunology who paid for my PhD and funded me as a pre-doctoral fellow

Why are famous journalists and anonymous virologists saying this??
They constantly attack me like this. Is it because my firsts are co-firsts? I was a team player and quite gracious and not avaricious with publications. I did not fight for glory so the postdocs I worked with got first position.
My contributions included finding the mechanism of T cell differentiation and how it was paracrine Via Fas and Akt.

You can read about it here govinfo.gov/content/pkg/FR…

What should I do about these people attacking me all the time?
Read 5 tweets
Anthony J Leonardi, PhD, MS Profile picture
Jan 24
So I am looking at the T cell changes in long covid in comparison to other infections

The CD8 naive T cell changes in covid are similar to what happens with naive CD8 T cells in nasty infections

Acute sars cov2 is indeed different, but Long Covid changes have me concerned ImageImage
I agree, there is a persistent activation that is driving differentiaion in Long Covid nature.com/articles/s4159…

This is similar to other infections but is NOT the same for a very important reason... ImageImage
The reason being there is no integration of the virus into DNA. sars cov 2 is not a retrovirus. Our therapies and vaccines should have good efficacy. There is also no direct replication in the T cells, but could be an immune reservoir. biorxiv.org/content/10.110…
Read 7 tweets
Anthony J Leonardi, PhD, MS Profile picture
Jan 23
There are sars cov 2 naive persons, and infection will bring an end to the pandemic sooner
Infection-based immunity has brought us closer to ending the pandemic by virtue of immunity
Infection-based immunity has prolonged the pandemic and borne new iterations of sars cov 2 that can reinfect and cause severe disease, despite T-cell memory
Read 6 tweets
Anthony J Leonardi, PhD, MS Profile picture
Jan 23
Guys, whenever you bring up that I have said T cells contribute to harm and people say I am a T cell contrarian, show them this paper, "T Cells: Warriors of SARS-CoV-2 Infection."

And have them read the part where it says T-cell memory may be harming
pubmed.ncbi.nlm.nih.gov/33277181/
In fact, it is in part this belief that I have what makes me so appalled at the infection of people for their immunity

Cov2 infection robs us of our naive T cells.

What does that mean for us with reinfections?
I warned that reinfections could get worse with the diminishing pool of naive t cells and the increased pool of memory T cells.

Now you all see the naive depletion

Welcome to the knowledge I've had since I saw the depletion long ago
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
Jan 23
This paper came out months after my preprint osf.io/2egsm/ but 2 weeks before my paper doi.org/10.3389/fimmu.… where I claimed T cell memory was contributing to harm in covid

It's cited 33 times and mine only 2

Balloux has made me self conscious about my H index lol
It's got such a feel-good title, "T cells- Warriors of sars cov 2 infection" Monica Gandhi even cited it by name about T cells in cov 2 infection

She must not have read it, lol, because it says the same thing I did, that memory t cells were harming pubmed.ncbi.nlm.nih.gov/33277181/
Next time I will be smart about making my write-ups more optimistic and accessible. It's got great paragraph headers.

Mine is all doom-y and even has apoptosis in the title. Noone wants to hear about that, lol frontiersin.org/articles/10.33…
Read 10 tweets

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