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Edgar V. Lerma 🇵🇭 Profile picture
@edgarvlermamd
Jan 26, 2022 • 5 tweets • 9 min read • Read on X
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PREDNOS 2: Evaluation of Daily Low-Dose Prednisolone During URTI to Prevent Relapse in Children w/ Relapsing Steroid-Sensitive Nephrotic Syndrome ca, 2022 from @JAMAPediatrics #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @drM_sudha

jamanetwork.com/journals/jamap…
Low-dose versus conventional-dose prednisolone for nephrotic syndrome relapses: a randomized controlled non-inferiority trial ca. 2022 from @Ped_Neph #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @md_abdulqader83

link.springer.com/article/10.100…
PREDNOS: Sixteen-week versus standard eight-week prednisolone therapy for childhood nephrotic syndrome ca. 2019 from @bmj_latest #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @jbda19

pubmed.ncbi.nlm.nih.gov/31156083/
Nice slide by @ArchanaVajjala summarizing the studies on dosing regimen of steroids for relapses in Steroid-sensitive Nephrotic Syndrome #NephJC #IPNAJC #Nephpearls
Treatment of MCD in children:
📌 Glucocorticoid-sparing therapies in children with Steroid Sensitive Nephrotic Syndrome (SSNS)
📌 Treatment of Steroid Resistant Nephrotic Syndrome (SRNS) in children

ca. 2021 from @goKDIGO #NephJC #IPNAJC #Nephpearls

👉 kdigo.org/wp-content/upl…

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More from @edgarvlermamd

Edgar V. Lerma 🇵🇭 Profile picture
Feb 26, 2022
Advancing Evidence-Based Care in Diabetes and CKD
#ISNWCN 🇲🇾 #Nephpearls

👉 kdigo.org/wp-content/upl…
Holistic approach for improving outcomes in patients with Diabetes and CKD
#ISNWCN 🇲🇾 #Nephpearls
Glucose-lowering agents in Type 2 Diabetes (T2D) and CKD: Indications and dose adjustments
#ISNWCN 🇲🇾 #Nephpearls
Read 9 tweets
Edgar V. Lerma 🇵🇭 Profile picture
Feb 26, 2022
.@goKDIGO Glomerular Diseases Guideline: Reflections on a Decade of Progress with @adrianliew8 @ReichHeather @Dr_KeishaGibson
#ISNWCN 🇲🇾 #Nephpearls

👉 kdigo.org/wp-content/upl…
IgA Nephropathy: A 1st step is in treating IgA Nephropathy is assessing "prognosis" based on data available at the time of biopsy

@goKDIGO suggest using the "prediction tool" that was derived from the largest & most geographically diverse cohort to date

#ISNWCN 🇲🇾 #Nephpearls
IgA Nephropathy: The @goKDIGO treatment algorithm recommends consideration of use of corticosteroids in patients with "persistent proteinuria >1g/day" if the risk/benefit profile is favorable

📌 A GFR of 30 is considered a threshold for treatment

#ISNWCN 🇲🇾 #Nephpearls
Read 13 tweets
Edgar V. Lerma 🇵🇭 Profile picture
Feb 23, 2022
First clinical-grade porcine 🐖 kidney xenotransplant using a human decedent model ca. 2022 from @amjtransplant #NephJC #Nephpearls

#VisualAbstract by @NamrataYParikh

👉🏼 pubmed.ncbi.nlm.nih.gov/35049121/ Image
Attitudes to Clinical Pig Kidney Xenotransplantation among Medical Providers and Patients ca. 2020 from @ASNKidney360 #Nephpearls

kidney360.asnjournals.org/content/1/7/657 ImageImage
Paving the Path toward Porcine Organs for Transplantation ca. 2017 from @NEJM #NephJC #Nephpearls

nejm.org/doi/full/10.10… ImageImage
Read 4 tweets
Edgar V. Lerma 🇵🇭 Profile picture
Jan 30, 2022
Nephrolithiasis 101: When to order a 24-hour urine collection #Nephpearls

Multiple or metabolically active stones (stones that increase in size/ number w/in a year)

Children

Demographic groups not typically prone to stone formation

Stones other than those containing calcium ImageImage
Interpretation of urine chemistries to identify lithogenic risk factors and assess the contribution of diet to the formation of kidney stones ca. 2016 from @ravineja #Nephpearls

sciencedirect.com/science/articl… Image
Neglected analytes in the 24 hour urine: ammonium and sulfate ca. 2021 from @CO_Neph_Hype @ravineja #Nephpearls

👉 pubmed.ncbi.nlm.nih.gov/34798636/ ImageImageImageImage
Read 4 tweets
Edgar V. Lerma 🇵🇭 Profile picture
Nov 17, 2021
Clinical Practice Guideline for the Management of Glomerular Diseases ca. 2021 from @goKDIGO #NephJC #Nephpearls
#VisualGraphics by @michaelturk6

Executive Summary pubmed.ncbi.nlm.nih.gov/34556300/
Full Guideline pubmed.ncbi.nlm.nih.gov/34556256/
The spectrum of glomerular diseases from @neilturn #NephJC #Nephpearls

👉 global.oup.com/academic/produ…
Nephrotic range proteinuria does "not always" mean nephrotic syndrome #NephJC #Nephpearls

👉 pubmed.ncbi.nlm.nih.gov/34556256/
Read 4 tweets
Edgar V. Lerma 🇵🇭 Profile picture
Nov 5, 2021
Mineralocorticoid receptor (MR) has a role in:
👉 BP regulation
👉 Electrolyte Homeostasis

Overactivation of MR leads to:
👉 Inflammation and Fibrosis
👉 Sodium retention

#KidneyWk #Nephpearls #Cardiorenal ImageImage
Finerenone: potent and selective non-steroidal MR antagonist (MRA) that is distinct from steroidal MRAs

#KidneyWk #Nephpearls #Cardiorenal ImageImage
FIDELITY pre-specified pooled analysis
👉 FIDELIO-DKD
👉 FIGARO-DKD
#KidneyWk #Nephpearls #Cardiorenal ImageImageImageImage
Read 4 tweets

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