Biotech2k Profile picture
Feb 2 9 tweets 3 min read
Top Tech in Biotech names.

Looking at top 3 companies using #AI, #ML, #Automation, #DeepLearning and #CAD in biotech drug discovery.
This is one space where I have a very hard time picking a favorite out of my top 3 of $SDGR, $RXRX and $EXAI. Each of these companies is using technology in a very powerful way to drive drug discovery.
It can take many years and over $1 billion in cost to developing a drug as 90% of new science fails to reach commercial. That is due to most of biotech being trial and error. By using technology, we can lower the cost and improve the chances of success.
First is $RXRX which is using automation by taking robots and having them run millions of experiments per week. All that data is recorded and built into a super computer that uses AI and Machine learning to use that data to discover new drugs and new uses for old drugs.
Then comes $SDGR which is using Computer Aided Design to develop software that predicts the movement and functions of proteins. This allows them to develop better drugs that target these proteins.
The last is one of my favorites and has 2 platforms. $EAXI uses AI and Machine learning to take all the known research and data and use it to drive drug discovery.
The other platform takes a single cell from a tumor and uses the genetics of that cell to pick the perfect treatment option for that specific tumor. This is all about personalized medicine. They showed they could improve outcomes by 30% over current standard of care.
This is one of my favorite spaces for the next decade or more. Its also one space where I find the most reluctance and skepticism by investors. That means its still in its infancy and cheap. Its hasn't seen mass investor adoption yet.
The tech investors don't understand the biotech side and the biotech investors don't seem to get the tech side. That makes it a good place a versatile investor to get in early.

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Biotech2k

Biotech2k Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @Biotech2k1

Feb 4
1/ Looking at Hypoimmune from $SANA

This is the data release from the NHP data.
2/ First demonstration of the survival of allogeneic iPSCs transplanted into an immunocompetent non-human primate model without the need for immune suppression
3/ Transplanting allogeneic cells into a primate without immune suppression represents a key step toward widespread treatment of disease using engineered cells
Read 14 tweets
Feb 4
1/ Looking at Hypoimmune from $SANA

This is from the 10K and not my original work.
2/ Designing Hypoimmune Cells
Our goal is to create a universal cell that is able to evade immune detection, regardless of cell type or transplant location.
3/ Our first-generation
technology, which is progressing through late-stage animal confirmatory studies, combines the three gene modifications below to hide these cells from
the host immune system:
Read 12 tweets
Feb 4
1/ Looking at Fusogen:

This is right from the 10K so Its not my original work, but I don't think I could say it any better.
2/ Background on Fusogens:

Fusogens are a well-studied class of naturally occurring proteins that mediate the trillions of cell-to-cell and intracellular fusion events occurring
in the human body every second.
3/ In 2013, the Nobel Prize in Physiology or Medicine was awarded for the elucidation of the roles of fusogens in
mediating intracellular trafficking in nature. First, fusogens enable recognition of a specific target membrane.
Read 23 tweets
Feb 4
Hidden Gems:

I think $SANA is one of the most hidden gems of all. They have 2 technology platforms with Fusogen and iPSC. Both of these programs could make them one of the biggest potential success stories off all time.
The Fusogen is a delivery vector for in-vivo editing with a much larger carrying capacity. They are targeting in-vivo editing of CAR-T cells. Imagine creating the Autologous CAR-T cells right inside the patient. The amount of cost and time that could be saved.
They can also target the liver and stem cells with this vector for delivery. I think we could see them do in-vivo stem cell corrections like for SCD in the coming years.
Read 7 tweets
Feb 3
Right now, It is all about the inflation equation. The companies making money right now are trading at bubbly valuations because no one wants to bet on growth companies that promise to make billions 10 years from now. They fear inflation will destroy that promise of growth. $XBI.
As soon as inflation peaks, you will see the rotation begin to move back to growth as value is a bubble. Probably worse then growth was last year. The problem here is the market is sticking with value as it seems the Fed is moving too slowly on getting inflation under control.
This gives you time to sell value, raise cash and slowly nibble away at those growth names while everyone else is scared and hiding in value. I honestly don't know how long it will take to see inflation abate and the switch to flip, but I am willing to buy now and wait.
Read 4 tweets
Feb 2
Look at the top #CellTherapies.

This is the space that is taking on using stem cells to develop therapies to target diseases.
The cell therapy space is vast, but its my opinion that many of these companies are not even close to being in the right place for the future. Many companies are harvesting cells and editing them. That is just slow and costly.
The future of this space will be to grow trillions of these cells from iPSC cells. This technology offers low cost, high doses and perfect consistency. My top 3 names in this space will be $SANA, $FATE, and $IPSC but I think I will also add is $CRSP.
Read 9 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

:(