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Anthony J Leonardi, PhD, MS Profile picture
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Feb 6 • 4 tweets • 2 min read
It's really not hard guys

T cells help you until they don't

Find the difference and you Win

There are two theories and then my own, which is under review: 1/🧵
2/ The first theory is from de Candia. They claimed that
1) young t cells act more precisely on cov2's epitopes thanks to a broad repertoire
2) memory t cells in older people contribute to inflammation pubmed.ncbi.nlm.nih.gov/33277181/
The second theory is Petter Brodin's theory regarding energy allocation.
My theory is under review

If you have a theory regarding the double-edged nature of T cell immunity in SARS Cov 2 post it or publish it

Do not pontificate over and over. We are just seeing now that they are harmed via Fas- something I wrote about targeting in 2020!

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More from @fitterhappierAJ

Anthony J Leonardi, PhD, MS Profile picture
Feb 4
A fact then a bit of speculation as my contribution:

fact: Naive T cells are a correlate of protection independent of age (but it correlates)

Speculation: As sars cov 2 infections greatly deplete Naive T cells, there may be a point where decompensation occurs (less protection)
Of course this is a dynamic relationship where other elements of the immune system can contribute to protection like antibodies and primed memory

But there is a natural sloughing and aging of the immune system

More to come on this
In cases where there is antibody escape the T cell dynamics are weighed more heavily, which is what we see often with these sera-evading variants and with titer waning
Read 6 tweets
Anthony J Leonardi, PhD, MS Profile picture
Feb 3
I have been delivering this message of the differentiating and dying T cells in the news since October 2020, have a read agenciasinc.es/Reportajes/Los…

tvanouvelles.ca/2022/02/01/une… (not me)

farodevigo.es/sociedad/2022/…
Lots of articles now, and some in agreement. What do you all think? ImageImage
My recommendation for targeting Fas-mediated death (My mechanistic contribution in the pandemic) is being pursued in France. What do you guys think?

BTW I had the idea in January 2020. I noticed the signs of lymphocyte death in the publications out of China. ImageImage
This has been tough because many people sought to discredit me and make promises about T cell immunity that simply were not true

They actually have been quite abusive for over a year with derision and ridicule... but I was right Image
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
Feb 3
Before I relayed the message, did you believe Cov2 induced Alzheimer's or Parkinson's like neuropathology?
When I relayed the message, did you then believe Cov2 induced Alzheimer's or Parkinson's like neuropathology?
Did you see other Scientists or laypeople disparage my warning of neuropath, and did you believe them or me?
Read 5 tweets
Anthony J Leonardi, PhD, MS Profile picture
Feb 2
Before I told you, did you think Covid kills T cells?
After I told you, did you believe it or find it too speculative?
Now that T cell apoptosis via Fas is shown to occur in Severe disease, do you believe it?

nature.com/articles/s4141…
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
Jan 29
If you look really close you can see they might be about to maintain a phase of "Getting Immunity™"
And your reminder that Omicron infection confers low immunity to Omicron
Also, according to this preprint, the breakthrough infection did not raise delta titers?
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
Jan 25
If I was a journalist and was this wrong about how immunity and evolution worked I would retire my pen.
An important arm of the long con about Endemic Vs. Pandemic
Spoiler: we are now in a world of immune escape if you hadn't noticed

Omicron infection confers poor titers. heck, all infection does

Nice job downplaying
Read 6 tweets

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