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Anthony J Leonardi, PhD, MS Profile picture
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Jan 29 • 4 tweets • 2 min read
If you look really close you can see they might be about to maintain a phase of "Getting Immunity™"
And your reminder that Omicron infection confers low immunity to Omicron
Also, according to this preprint, the breakthrough infection did not raise delta titers?
We are entering @ChristosArgyrop' Oscillator

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More from @fitterhappierAJ

Anthony J Leonardi, PhD, MS Profile picture
Jan 25
If I was a journalist and was this wrong about how immunity and evolution worked I would retire my pen.
An important arm of the long con about Endemic Vs. Pandemic
Spoiler: we are now in a world of immune escape if you hadn't noticed

Omicron infection confers poor titers. heck, all infection does

Nice job downplaying
Read 6 tweets
Anthony J Leonardi, PhD, MS Profile picture
Jan 25
In order for propaganda megaphones that cite Gupta on continuous reinfection being 'herd immunity' to sell the idea to the public they must first convince you all that reinfections will be more mild.

It's not the case. It depends on your immune system and other factors.
We are entering total information control. We have sources on the right claiming this is a safe route to endemicity and sources on the left like Zeynep that call me a crank for warning about severe reinfections, t cell harm, and t cell mediated harm.
These narratives coalesce and appear as a consensus to the public. A struggle ensues between authorities that want to power through endemicity versus those that want to mitigate a multi-pandemic of a diversifying set of viruses which emerged from wuhan 1.0
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
Jan 24
Damn, Zeynep is absolutely brutal

I'm not the only one who has said overshooting T cell responses have contributed to harm and not controlled cov 2 infection

Read these papers before you say I am the only one with this idea (I published it earlier)

This is so insanely disrespectful and unbecoming.

Have T cells stopped severe infections or has t cell memory stopped the pandemic

No!

Stop overselling T cell memory!!

All your BS has harmed T cells by overselling infection based immunity!
helsinki.fi/en/news/health… Here is a seminar where the likelihood of T cell mediated harm is discussed in Covid-19

This is becoming clear now!
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
Jan 24
This is insane. I have two co-firsts in JCI and JCI insight on T-cell differentiation out of the surgery branch of the NCI, a famous place for immunology who paid for my PhD and funded me as a pre-doctoral fellow

Why are famous journalists and anonymous virologists saying this??
They constantly attack me like this. Is it because my firsts are co-firsts? I was a team player and quite gracious and not avaricious with publications. I did not fight for glory so the postdocs I worked with got first position.
My contributions included finding the mechanism of T cell differentiation and how it was paracrine Via Fas and Akt.

You can read about it here govinfo.gov/content/pkg/FR…

What should I do about these people attacking me all the time?
Read 5 tweets
Anthony J Leonardi, PhD, MS Profile picture
Jan 24
So I am looking at the T cell changes in long covid in comparison to other infections

The CD8 naive T cell changes in covid are similar to what happens with naive CD8 T cells in nasty infections

Acute sars cov2 is indeed different, but Long Covid changes have me concerned ImageImage
I agree, there is a persistent activation that is driving differentiaion in Long Covid nature.com/articles/s4159…

This is similar to other infections but is NOT the same for a very important reason... ImageImage
The reason being there is no integration of the virus into DNA. sars cov 2 is not a retrovirus. Our therapies and vaccines should have good efficacy. There is also no direct replication in the T cells, but could be an immune reservoir. biorxiv.org/content/10.110…
Read 7 tweets
Anthony J Leonardi, PhD, MS Profile picture
Jan 23
There are sars cov 2 naive persons, and infection will bring an end to the pandemic sooner
Infection-based immunity has brought us closer to ending the pandemic by virtue of immunity
Infection-based immunity has prolonged the pandemic and borne new iterations of sars cov 2 that can reinfect and cause severe disease, despite T-cell memory
Read 6 tweets

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