Kudos @RealMilesBerger and team for this study
onlinelibrary.wiley.com/doi/full/10.10…
I made a brief🧵from my perspective as people keep asking me about these findings (and I love discussing about this topic):
onlinelibrary.wiley.com/doi/full/10.10…
I made a brief🧵from my perspective as people keep asking me about these findings (and I love discussing about this topic):
26% of older adults had changes in at least 1 cognitive domain 6 weeks after surgery, not a negligible number. This was unrelated to CSF changes in AD biomarkers and remains unknown what drives this dysfunction in these subjects...
From this same clinical cohort we have shown that resolving lipid mediators and non-resolving inflammation may contribute to changes in cognitive trajectories (or PND) but the sample size was limited in order to be conclusive on these new CSF biomarkers.
nature.com/articles/s4159…
nature.com/articles/s4159…
#delirium was not assessed in the current study but changes in CSF amyloid were previously described in patients with delirium after orthopedic surgery. This is a much more acute and different evaluation of cognitive domains than PND @asjdseesit.
journals.lww.com/annalsofsurger…
journals.lww.com/annalsofsurger…
Finally, #delirium and PND are different pathologies. Severe delirium can associate with AD/ADRD @NIDUS_Delirium @sharon_inouye. I found it reassuring that PND in older adults is less apt to evoke similar pathology as measured in #Alzheimer.
agsjournals.onlinelibrary.wiley.com/doi/10.1111/jg…
agsjournals.onlinelibrary.wiley.com/doi/10.1111/jg…
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