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Luca Arcari Profile picture
@Luca_Arcari88
Feb 11, 2022 • 8 tweets • 3 min read • Read on X
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1/ Case of te day, classic #HCM @beamusumeci1 @TiniGiacomo @domitillarusso
2/ Bright area in the LV septum/anteriore wall, seen already from trufi scout ... #WhyCMR
3/ That is edema (T2 STIR)
4/ Classic LGE at insertion points, not so large, not a bad prognostic sign. Edema partly matches scarred area
5/ Native T1 assessed outside scarred area, increased (diffuse fibrosis/edema)
6/ normal T2 in the area of increase T1 (fibrosis more than edema) - increased T2 (>50 msec) within the bright Stir region. Kill the colours by windowing, parametric assesment of T2 maps is more reliable than visual evaluation
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The missing T2 map

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More from @Luca_Arcari88

Luca Arcari Profile picture
Sep 10, 2023
(1/9) Interesting study recently published in @ehj_ed providing a comprehensive description of microvascular function in an animal model of 💔#takotsubo💔 - however, can we call it a microvascular disease? Some thoughts to challenge this view (thread 🧵)academic.oup.com/eurheartj/arti…
(2/9) The authors used transaortic contriction to elicit #takotsubo in mice. They performed it on mice null for Kv1.5 channels and double transgenic mice with inducible Kv1.5 (plus controls): this elegantly reiterates the role of microvascular dysfunction (MD)...
(3/9)...as a relevant predisposing or contributing factor for #takotsubo, yet it does not demonstrate its pivotal action. In an animal model of isoprenaline induced #takotsubo MD was absent minutes after ballooning onset, implying that...academic.oup.com/ehjcimaging/ar…
Read 11 tweets
Luca Arcari Profile picture
Mar 8, 2023
Glad to share our latest publication on #WhyCMR with T1 and T2 mapping in #takotsubo syndrome 😊with @lucarlimite @beamusumeci1 @c_eike @v_puntmann academic.oup.com/ehjcimaging/ad…
Myocardial edema largely represented, correlations with interstitial expansion, ECG changes and systolic function. Some considerations below 🧵
1/ In #takotsubo syndrome myocardial edema features the acute phase: #WhyCMR T1 and T2 mapping have the advantage of a parametric quantification of edema. T2 specific for water, but native T1 can read it too (ahajournals.org/doi/full/10.11…) and ECV not water-independent in this setting
Read 9 tweets
Luca Arcari Profile picture
May 24, 2022
😊 first-authorship on @JACCjournals❗️ @beamusumeci1 jacc.org/doi/abs/10.101… - Thankful to @FraSantoroMD, Prof. ND Brunetti, @IngoEitel @t_stiermaier and @ibnsky for this collaboration and for setting up the #GEIST registry on its very beginning - few considerations below 🧵
1/8 Males represent approx. 10% of #Takotsubo patients within the registry. As comapred with females, they have ⬆️comorbid burden (malignancies, COPD etc.), ⬆️physical trigger ⬇️LVEF, worse in-hospital and long-term outcome.
2/8 These results were expected, when looking at smaller previously published studies, but why is that? Is the #takotsubo attack itself worse in men or do they just suffer because of the vulnerable comorbid background?
Read 10 tweets
Luca Arcari Profile picture
Feb 9, 2022
No, non è un bene scaricare le responsabilità sulla magistratura (thread) 🧵
@corzunino @PrecariUnitINFN @IoNonFaccioNien @MC_Carro
1/ Premessa - “Nell’università italiana il reclutamento segue nei fatti logiche slegate dai regolamenti concorsuali ”
Senza polemiche e moralismi, se si nega questo stato dell’arte, si può interrompere qua la lettura
2/ Il reclutamento nell’accademia è fatto di cooptazione, in Italia come nel resto del mondo. Necessariamente, per selezionare, il giudizio deve essere espresso da chi è esperto della materia, il cortocircuito è inevitabile e i grandi grant internazionali non ne sono esenti
Read 11 tweets
Luca Arcari Profile picture
Jun 12, 2021
Finally published on @journalofCMR!!! Cardiac biomarkers and #WhyCMR T1 and T2 mapping in people with chronic kidney disease - Thanks to @GoetheCVI @v_puntmann @c_eike jcmr-online.biomedcentral.com/articles/10.11… Few considerations below.
We found independent associations between increasing natriuretic peptide/hsTropT on one side and myocardial involvement as assessed by native T1 and T2 mapping on the other ➡️ cardiac biomarkers=cardiac involvement (not only reduced elimination). (1/3)
Is cardiac involvement characterized by diffuse fibrosis only? Likely not: increased T2=contribution of myocardial edema. ❗️❗️T2 decreases after hemodialysis, proportionally to revomed volume❗️❗️ (2/3)
Read 6 tweets
Luca Arcari Profile picture
Sep 28, 2020
Just published our latest work.

Investigating myocardial involvement in #COVID19 by troponin and BNP: dual center study on the first wave in Lazio region, Italy. link.springer.com/article/10.100… @mikeolangel @beamusumeci1 @P_Martelletti. Here it follows some considerations.
1. Increase of troponin/BNP was common in our sample, higher in patients with worse in-hospital prognosis (consistently shown in literature). Take into account epidemiological characteristics of the population: older age, high rate of comorbidity and fatal outcome.
2. Troponin and BNP generally had parallel increase, both in relation to A) markers of disease severity (D-dimer, CRP, P/F) and B) pre-existing condition of vulnerability (age, previous CVD, renal insufficiency etc.). However,
Read 7 tweets

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